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Advanced prostate cancer: Reinforcing the strings between inflammation and the metastatic behavior
(Nature Publishing Group, 2012-09)
It is currently estimated that inflammatory responses are linked to 15-20% of all deaths from cancer worldwide. Although many studies point to an important role of inflammation in prostate growth, the contribution of ...
Avances en el tratamiento de cáncer de próstata resistente a la castración: énfasis en nuevas terapias hormonales
(Sociedad Médica de Santiago, 2015)
Prostate cancer represents the second cancer-related cause of death in North American and Chilean men. The main treatment for incurable stages of disease is surgical or pharmacological castration. However, with time and ...
Androgen receptor signaling in prostate cancer: Genetic and molecular aspects
(2014-01-01)
The prostate is an accessory sex gland of the male reproductive system, which produces alkaline prostatic fluid, capable of ensuring the spermatic viability to fertilize eggs within the female reproductive system. Functionally, ...
Avances en el tratamiento de cáncer de próstata resistente a la castración: énfasis en nuevas terapias hormonales
(Sociedad Médica de Santiago, 2015)
Prostate cancer represents the second cancer-related cause of death in North American and Chilean men. The main treatment for incurable stages of disease is surgical or pharmacological castration. However, with time and ...
Tumour cell lysate-loaded dendritic cell vaccine induces biochemical and memory immune response in castration-resistant prostate cancer patients
(2013)
Background: Recently, we produced a tumour antigen-presenting cells (TAPCells) vaccine using a melanoma cell lysate, called TRIMEL, as an antigen source and an activation factor. Tumour antigen-presenting cells induced ...
Cross-Resistance to Abiraterone and Enzalutamide in Castration Resistance Prostate Cancer Cellular Models Is Mediated by AR Transcriptional Reactivation
Androgen deprivation therapy (ADT) and novel hormonal agents (NHAs) (Abiraterone and Enzalutamide) are the goal standard for metastatic prostate cancer (PCa) treatment. Although ADT is initially effective, a subsequent ...
Heme oxygenase 1 governs the cytoskeleton at filopodia: pulling the brakes on the migratory capacity of prostate tumoral cells
(Nature Publishing Group-Springer, 2017-04)
This paper refers to Paez et al.1 Prostate cancer (PCa) is the second leading cause of cancer death in men in the United States.2 Incidence increases with patient age and represents the most important risk factor. Localized ...
Commentary: Arginine vasopressin receptor 1a is a therapeutic target for castration-resistant prostate cancer
(Frontiers Media, 2020-01-10)
Prostate cancer patients managed with androgen-deprivation therapy usually recur after a few years and the disease gradually becomes castration-resistant prostate cancer (CRPC). The role of tumor cell plasticity, including ...