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Gender differences in cardiac left ventricular mass and function: clinical and experimental observations
(Via Medica, 2014-01)
Background: The aim of this study was to evaluate gender-associated impact on left ventricular mass (LVM) and on left ventricular function (LVF) in humans and rats with aging. Methods: Myocyte area and collagen volume ...
Effect of inhibitors of signal transduction on IGF-1-induced protein synthesis associated with hypertrophy in cultured neonatal rat ventricular myocytes
(ELSEVIER SCIENCE BV, 1998-01-30)
IGF-1 increased 2-fold protein synthesis in cardiac myocytes. Genistein, whether added during preincubation or with IGF-I at the start of incubation, significantly inhibited the IGF-1-induced stimulation of protein synthesis, ...
Voluntary exercise-induced changes in β2-adrenoceptor signalling in rat ventricular myocytes
(Experimental Physiology, 2018)
GSK-3 beta/NFAT Signaling Is Involved in Testosterone-Induced Cardiac Myocyte Hypertrophy
(2016)
Testosterone induces cardiac hypertrophy through a mechanism that involves a concerted crosstalk between cytosolic and nuclear signaling pathways. Nuclear factor of activated T-cells (NFAT) is associated with the promotion ...
GSK-3β/NFAT Signaling is involved in testosterone-induced cardiac myocyte hypertrophy
(Public Library Science, 2016-12-15)
Testosterone induces cardiac hypertrophy through a mechanism that involves a concerted crosstalk between cytosolic and nuclear signaling pathways. Nuclear factor of activated Tcells (NFAT) is associated with the promotion ...
Acute inhibition of excessive mitochondrial fission after myocardial infarction prevents long-term cardiac dysfunction
(Wiley-BlackwellOxford, 2013-10-08)
BACKGROUND:
Ischemia and reperfusion (IR) injury remains a major cause of morbidity and mortality and multiple molecular and cellular pathways have been implicated in this injury. We determined whether acute inhibition ...
Memantine prevents cardiomyocytes nuclear size reduction in the left ventricle of rats exposed to cold stress
(Faculdade de Medicina / USP, 2009-01-01)
OBJECTIVES: Memantine is an N-methyl-d-aspartate (NMDA) glutamate receptor antagonist used to treat Alzheimer's disease. Previous studies have suggested that receptor blockers act as neuroprotective agents; however, no ...