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Experimental assessment of a myocyte-based multiscale model of cardiac contractile dysfunction
(Academic Press Ltd - Elsevier Science Ltd, 2018-11)
Cardiac contractile dysfunction (CD) is a multifactorial syndrome caused by different acute or progressive diseases which hamper assessing the role of the underlying mechanisms characterizing a defined pathological condition. ...
AMPK-dependent nitric oxide release provides contractile support during hyperosmotic stress
(Dr Dietrich Steinkopff Verlag, 2018-01)
In different pathological situations, cardiac cells undergo hyperosmotic stress (HS) and cell shrinkage. This change in cellular volume has been associated with contractile dysfunction and cell death. Given that nitric ...
Calcium/Calmodulin Protein Kinase II-Dependent Ryanodine Receptor Phosphorylation Mediates Cardiac Contractile Dysfunction Associated with Sepsis
(Lippincott Williams, 2017-04)
Objectives: Sepsis is associated with cardiac contractile dysfunction attributed to alterations in Ca2+ handling. We examined the subcellular mechanisms involved in sarcoplasmic reticulum Ca2+ loss that mediate altered ...
Myocardial Dysfunction in Cirrhotic Cardiomyopathy is Associated with Alterations of Phospholamban Phosphorylation and IL-6 Levels
(Elsevier B.V., 2021-04-01)
Background. Decreased cardiac contractility has been observed in cirrhosis, but the mechanisms that initiate and maintain cardiac dysfunction are not entirely understood. Aim of the study. We test the hypothesis that ...
Obesity Resistance Promotes Mild Contractile Dysfunction Associated with Intracellular Ca2+ Handling
(Arquivos Brasileiros Cardiologia, 2015-12-01)
Background: Diet-induced obesity is frequently used to demonstrate cardiac dysfunction. However, some rats, like humans, are susceptible to developing an obesity phenotype, whereas others are resistant to that. Objective: ...
Myocardial contractile dysfunction contributes to the development of heart failure in rats with aortic stenosis
(Elsevier B.V., 2007-04-12)
Objectives: To analyze the potential contribution of contractility state and ventricular geometry to the development of heart failure in rats with aortic stenosis.Methods: Rats were divided into three groups: compensated ...
Myocardial contractile dysfunction contributes to the development of heart failure in rats with aortic stenosis
(Elsevier B.V., 2007-04-12)
Objectives: To analyze the potential contribution of contractility state and ventricular geometry to the development of heart failure in rats with aortic stenosis.Methods: Rats were divided into three groups: compensated ...