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Multiscale modelization in a small virus: Mechanism of proton channeling and its role in triggering capsid disassembly
(Public Library of Science, 2018-04-16)
In this work, we assess a previously advanced hypothesis that predicts the existence of ion channels in the capsid of small and non-enveloped icosahedral viruses. With this purpose we examine Triatoma Virus (TrV) as a case ...
X-ray structure of Triatoma virus empty capsid: Insights into the mechanism of uncoating and RNA release in dicistroviruses
(Society for General Microbiology, 2016-10)
In viruses, uncoating and RNA release are two key steps of successfully infecting a target cell. During these steps, the capsid must undergo the necessary conformational changes to allow RNA egress. Despite their importance, ...
Cryo-electron microscopy reconstructions of triatoma virus particles: a clue to unravel genome delivery and capsid disassembly
(Society For General Microbiology, 2013-03)
Triatoma virus (TrV), a positive-sense ssRNA virus with a small spherical non-enveloped capsid of ~300 Å in diameter ( Muscio et al., 1988 ; Czibener et al., 2000 ), belongs to the genus Cripavirus (type species: cricket ...
Probing the biophysical interplay between a viral genome and its capsid
(Nature Publishing Group, 2013-04-28)
The interaction between a viral capsid and its genome governs crucial steps in the life cycle of a virus, such as assembly and genome uncoating. Tuning cargo–capsid interactions is also essential for successful design and ...
Expression and characterization of HPV-16 L1 capsid protein in Pichia pastoris
(SPRINGER WIEN, 2009)
Human papillomaviruses (HPVs) are responsible for the most common human sexually transmitted viral infections. Infection with high-risk HPVs, particularly HPV16, is associated with the development of cervical cancer. The ...
The role of viral particle integrity in the serological assessment of foot-and-mouth disease virus vaccine-induced immunity in swine
(Public Library of Science, 2020-05)
The efficacy of foot-and-mouth disease virus (FMDV) inactivated vaccines is mainly dependent on the integrity of the whole (146S) viral particles. If the intact capsids disassemble to 12S subunits, antibodies against ...
The role of viral particle integrity in the serological assessment of foot-and-mouth disease virus vaccine-induced immunity in swine
(Plos One, 2020-05)
The efficacy of foot-and-mouth disease virus (FMDV) inactivated vaccines is mainly dependent on the integrity of the whole (146S) viral particles. If the intact capsids disassemble to 12S subunits, antibodies against ...