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Differential expression of canalicular membrane Ca2+/Mg2+-ecto-ATPase in estrogen-induced and obstructive cholestasis in the rat
(MOSBY, INC, 2000)
Extracellular adenosine triphosphate (ATP) may regulate hepatocyte and cholangiocyte functions, and under some conditions it may have deleterious effects on bile secretion and cause cholestasis. The canalicular membrane ...
Enrichment of canalicular membrane with cholesterol and sphingomyelin prevents bile salt-induced hepatic damage
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 1999)
These studies were undertaken to characterize the role of plasma membrane cholesterol in canalicular secretory functions and hepatocyte integrity against intravenous taurocholate administration. Cholesterol and sphingomyelin ...
ENHANCED BILIARY-EXCRETION OF CANALICULAR MEMBRANE ENZYMES IN ETHYNYLESTRADIOL-INDUCED CHOLESTASIS - EFFECTS OF URSODEOXYCHOLIC ACID ADMINISTRATION
(PERGAMON-ELSEVIER SCIENCE LTD, 1995)
Cholestasis is associated with a marked increase in the release of canalicular membrane enzymes into bile. This phenomenon has been related to an increased lability of these canalicular membrane integral proteins to the ...
ASSOCIATION OF CANALICULAR MEMBRANE ENZYMES WITH BILE-ACID MICELLES AND LIPID AGGREGATES IN HUMAN AND RAT BILE
(ELSEVIER SCIENCE BV, 1995)
This study was undertaken to gain insights into the characteristics of the polymolecular association between canalicular membrane enzymes, bile acids, cholesterol and phospholipids in bile and into the cellular mechanisms ...
Prevention of estradiol 17β-d-glucuronide– induced canalicular transporter internalization by hormonal modulation of cAMP in rat hepatocytes
(American Society for Cell Biology, 2011-08)
In estradiol 17β-d-glucuronide (E17G)–induced cholestasis, the canalicular hepatocellular transporters bile salt export pump (Abcb11) and multidrug-resistance associated protein 2 (Abcc2) undergo endocytic internalization. ...
Fibrates induce mdr2 gene expression and biliary phospholipid secretion in the mouse
(PORTLAND PRESS LTD, 1996)
Disruption of the murine mdr2 gene leads to the complete absence of biliary phospholipids. We tested the hypothesis that the increase in biliary phospholipid output induced by fibrates is mediated via induction of the ...
Hepatocyte aquaporins in bile formation and cholestasis
(Frontiers In Bioscience Inc, 2011-06)
Bile formation by hepatocytes is an osmotic secretory process that is ultimately dependent on the biliary secretion of osmotically-active solutes (mainly bile salts) via specialized canalicular transporters as well as on ...