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Aging and CaMKII alter intracellular Ca2+ transients and heart rhythm in Drosophila Melanogaster
(Public Library Of Science, 2014-07)
Aging is associated to disrupted contractility and rhythmicity, among other cardiovascular alterations. Drosophila melanogaster shows a pattern of aging similar to human beings and recapitulates the arrhythmogenic conditions ...
Chasing cardiac physiology and pathology down the CaMKII cascade
(American Physiological Society, 2015-02)
Calcium dynamics is central in cardiac physiology, as the key event leading to the excitation-contraction coupling (ECC) and relaxation processes. The primary function of Ca2+ in the heart is the control of mechanical ...
CaMKII isoforms in learning and memory: Localization and function
(Frontiers Research Foundation, 2018-12)
Calcium/calmodulin-dependent protein kinase II (CaMKII) is a key protein kinase in neural plasticity and memory, as have been shown in several studies since the first evidence in long-term potentiation (LTP) 30 years ago. ...
Reversal of synaptic memory by Ca2+/calmodulin-dependent protein kinase II inhibitor
(2007)
Long-term potentiation (LTP) is an activity-dependent strengthening of synapses that is thought to underlie memory storage. Ca2+/ calmodulin-dependent protein kinase II (CaMKII) has been a leading candidate as a memory ...