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The role of apoptosis proteins and complement components in the etiopathogenesis of systemic lupus erythematosus
(Faculdade de Medicina / USP, 2010)
Systemic lupus erythematosus is a prototypical autoimmune disease characterized by the deregulation of T and B cells, tissue infiltration by mononuclear cells, tissue damage and the production of autoantibodies. There is ...
Neutrophil Extracellular Traps: A Perspective of Neuroinflammation and Complement Activation in Alzheimer’s Disease
(2021-04-08)
Complement system (CS) components are associated with Alzheimer’s disease (AD), the commonest cause of dementia in the world. Neutrophils can be attracted to amyloid-β plaques by several pro-inflammatory factors, including ...
The Interactions of Parasite Calreticulin With Initial Complement Components: Consequences in Immunity and Virulence
(Frontiers Media, 2020)
Because of its capacity to increase a physiologic inflammatory response, to stimulate phagocytosis, to promote cell lysis and to enhance pathogen immunogenicity, the complement system is a crucial component of both the ...
F(ab')2 antibody fragments against Trypanosoma cruzi calreticulin inhibit its interaction with the first component of human complement
(Sociedad de Biología de Chile, 2005)
IMMUNOLOGICAL STUDIES IN PLACENTAS WITH VILLITIS OF UNKNOWN ETIOLOGY - COMPLEMENT COMPONENTS AND IMMUNOGLOBULINS IN CHORIONIC VILLI
(Walter De Gruyter & CoBerlinAlemanha, 1992)
Molecular mechanisms involved in the inactivation of the first component of human complement by Trypanosoma cruzi calreticulin
(ELSEVIER, 2010)
Trypanosoma cruzi (T. cruzi), the agent of Chagas’ disease, the sixth most important neglected tropical
disease worldwide, causes 50,000 deaths per year in Latin America. T. cruzi calreticulin (TcCRT), a highly
pleiotropic ...
The Interaction of Classical Complement Component C1 with Parasite and Host Calreticulin Mediates Trypanosoma cruzi Infection of Human Placenta
(2013)
Background: 9 million people are infected with Trypanosoma cruzi in Latin America, plus more than 300,000 in the United States, Canada, Europe, Australia, and Japan. Approximately 30% of infected individuals develop ...
F(ab')2 antibody fragments against Trypanosoma cruzi calreticulin inhibit its interaction with the first component of human complement
(Society of Biology of Chile, 2005)
Trypanosoma cruzi calreticulin (TcCRT), described in our laboratory, retains several important functional features from its vertebrate homologues. We have shown that recombinant TcCRT inhibits the human complement system ...
Complement and antibody primary immunodeficiency in juvenile systemic lupus erythematosus patients
(Sage Publications Ltd, 2011-10-01)
Objective: To evaluate the frequency of primary immunodeficiencies (PID) in juvenile systemic lupus erythematosus (JSLE) patients. Methods: Some 72 JSLE patients were analyzed for levels of immunoglobulin classes and IgG ...