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A specific and highly sensitive time-resolved fluoroimmunoassay for human proinsulin
(Assoc Bras Divulg Cientifica, 1996-02-01)
We describe a time-resolved fluoroimmunoaaaay specific for human Key words proinsulin using a combination of two high-affinity monoclonal antibodies, one against insulin and the other specific for intact proinsulin and for ...
Double immunogold method for the simultaneous ultrastructural localization of regulatory peptides
(JOURNAL OF HISTOCHEMISTRY AND CYTOCHEMISTRY, 2015)
Proinsulin serum concentrations in women with polycystic ovary syndrome: a marker of beta-cell dysfunction?
(OXFORD UNIV PRESS, 2003-12)
BACKGROUND: The aim of this study was to establish the effect of polycystic ovary syndrome (PCOS) adjusted for adiposity on proinsulin concentrations. METHODS: Ninety-one women with PCOS and 72 normal cycling (NC) women ...
Low levels of sex hormone-binding globulin and hyperproinsulinemia as markers of increased pancreatic ß-cell demand in men
(Associação Brasileira de Divulgação Científica, 1998-12-01)
Low levels of sex hormone-binding globulin (SHBG) are considered to be an indirect index of hyperinsulinemia, predicting the later onset of diabetes mellitus type 2. In the insulin resistance state and in the presence of ...
Evaluation of IDA-PEVA hollow fiber membrane metal ion affinity chromatography for purification of a histidine-tagged human proinsulin
(Elsevier Science BvAmsterdamHolanda, 2006)
Proinsulin C-peptide induces c-Jun N-terminal kinase 1 expression in LEII mouse lung capillary endothelial cells
(HOKKAIDO UNIV, 2009)
To characterize the roles of C-peptide in vascular homeostatic processes, we examined the genes regulated by C-peptide in LEII mouse lung microvascular endothelial cells. Treatment of the cells with C-peptide increased the ...
Correct targeting of proinsulin in protein storage vacuoles of transgenic soybean seeds
(Funpec-editoraRibeirao PretoBrasil, 2010)
TCF7L2 correlation in both insulin secretion and postprandial insulin sensitivity
(2018-04-26)
Abstract
Background
The TCF7L2 rs7903146 variant is strongly associated with type 2 diabetes mellitus (T2DM). However, the mechanisms involved in this association remain unknown ...
Insulin resistance and impaired glucose tolerance in overweight and obese Costa Rican schoolchildren
(2008)
Background. Worldwide obesity has become an unprecedented public health challenge. In addition, a notable increase in the risk of insulin resistance and type 2 diabetes mellitus has emerged. In Costa Rica, there are no ...