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Peptide prodrugs for the treatment of CNS disorders: A perspective for new drugs
(2014-01-01)
The treatment of central nervous system (CNS) diseases is a major challenge. The presence of the barrier intended to protect the brain from unwanted molecules also impairs the efficacy of CNS-targeted drugs. The discovery ...
Peptide Prodrugs for the Treatment of CNS Disorders: A Perspective for New Drugs
(Bentham Science Publ Ltd, 2014-01-01)
The treatment of central nervous system (CNS) diseases is a major challenge. The presence of the barrier intended to protect the brain from unwanted molecules also impairs the efficacy of CNS-targeted drugs. The discovery ...
Calming Down Mast Cells with Ketotifen: A Potential Strategy for Multiple Sclerosis Therapy?
(2019-01-01)
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS) characterized by extensive inflammation, demyelination, axonal loss and gliosis. Evidence indicates that mast cells contribute to ...
Peptide Prodrugs for the Treatment of CNS Disorders: A Perspective for New Drugs
(Bentham Science Publ Ltd, 2014)
Peptide Prodrugs for the Treatment of CNS Disorders: A Perspective for New Drugs
(Bentham Science Publ Ltd, 2014)
Calcitriol Prevents Neuroinflammation and Reduces Blood-Brain Barrier Disruption and Local Macrophage/Microglia Activation
(2020-03-12)
Multiple sclerosis (MS) is a progressive disease of the central nervous system (CNS) that involves damage to the myelin sheath surrounding axons. MS therapy is based on immunomodulatory drugs that reduce disease recurrence ...
The fly blood-brain barrier fights against nutritional stress
(SAGE, 2022)
In the wild, animals face different challenges including multiple events of food scarcity. How they overcome these conditions is
essential for survival. Thus, adaptation mechanisms evolved to allow the development and ...
Toxoplasma gondii: The severity of toxoplasmic encephalitis in C57BL/6 mice is associated with increased ALCAM and VCAM-1 expression in the central nervous system and higher blood-brain barrier permeability
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2010)
In order to investigate the differential ALCAM, ICAM-1 and VCAM-1 adhesion molecules mRNA expression and the blood-brain barrier (BBB) permeability in C57BL/6 and BALB/c mice in Toxoplasma gondii infection, animals were ...
Current state and future perspectives in QSAR models to predict blood-brain barrier penetration in central nervous system drug R&D
(Bentham Science Publishers, 2017-02)
The Blood-Brain Barrier (BBB) is a physical and biochemical barrier that restricts the entry of certain drugs to the Central Nervous System (CNS), while allowing the passage of others. The ability to predict the permeability ...