Specific kinetic rates are key variables regarding metabolic activity in bioprocesses. They are non-linear functions of concentrations and operating conditions and therefore of difficult access for process control. In this ...

This paper deals with the estimation of unknown signals in bioreactors using sliding observers. Particular attention is drawn to estimate the specific growth rate of microorganisms frommeasurement of biomass concentration. ...

Bioprocesses are characterized by the fact that small variations in operating conditions may have a substantial impact on the final batch quality. Therefore, the early detection and isolation of faults allow implementing ...

The yeast Saccharomyces cerevisiae can be useful in several ways in bioprocesses. It is widely used in anaerobic processes for production of bioethanol at Brazilians plants. It is also of great importance as baker s yeast, ...

This paper aims to solve the problem of tracking optimal profiles for a nonlinear multivariable fed-batch bioprocess by a simple but efficient closed-loop control technique based on a linear algebra approach. In the proposed ...

The problem of optimal profiles tracking control under uncertainties for a nonlinear fed-batch bioprocess is addressed in this paper. Based on the results reported by Pantano et al. [ Ind. Eng. Chem. Res. 2017, 56, 6043], ...

This work presents a general model-based methodology to scale-up fed-batch bioprocesses. The idea behind this approach is to establish a dynamics hierarchy, based on a model of the process, that allows the designer to ...