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The folding unit of phosphofructokinase-2 as defined by the biophysical properties of a monomeric mutant
(Biophysical Society, 2015)
© 2015 Biophysical Society. Escherichia coli phosphofructokinase-2 (Pfk-2) is an obligate homodimer that follows a highly cooperative three-state folding mechanism N<inf>2</inf> → 2I → 2U. The strong coupling ...
Determination of the Stoichiometry between α- and γ1 Subunits of the BK Channel Using LRET
(Biophysical Society, 2018)
© 2018 Biophysical Society Two families of accessory proteins, β and γ modulate BK channel gating and pharmacology. Notably, in the absence of internal Ca2+, the γ1 subunit promotes a large shift of the BK conductance-voltage ...
Tonic and phasic receptor neurons in the vertebrate olfactory epithelium
(Biophysical Society, 2003)
Olfactory receptor neurons (ORNs) respond to odorants with characteristic patterns of action potentials that are relevant for odor coding. Prolonged odorant exposures revealed three populations of dissociated toad ORNs, ...
Protons induce calsequestrin conformational changes
(Biophysical Society, 1996)
Calsequestrin, a high-capacity, intermediate-affinity, calcium-binding protein present in the lumen of sarcoplasmic reticulum, undergoes extensive calcium-induced conformational changes at neutral pH that cause distinct ...
Binding to phosphatidyl serine membranes causes a conformational change in the concave face of annexin I
(Biophysical Society, 1997)
Recent studies have revealed that binding of annexin I to phospholipids induces the formation of a second phospholipid binding site. It is shown that the N terminus on the concave side of membrane-bound annexin I is cleaved ...