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Differential effects of TR ligands on hormone dissociation rates: Evidence for multiple ligand entry/exit pathways
(PERGAMON-ELSEVIER SCIENCE LTD, 2009)
Some nuclear receptor (NR) ligands promote dissociation of radiolabeled bound hormone from the buried ligand binding cavity (LBC) more rapidly than excess unlabeled hormone itself This result was interpreted to mean that ...
Ligand and structure-based modeling of passive diffusion through the blood-brain barrier
(Bentham Science Publishers B.V., 2018)
Computational Biology Tools for Identifying Specific Ligand Binding Residues for Novel Agrochemical and Drug Design
(Bentham Science Publ Ltd, 2015-01-01)
The term agrochemicals is used in its generic form to represent a spectrum of pesticides, such as insecticides, fungicides or bactericides. They contain active components designed for optimized pest management and control, ...
Computational biology tools for identifying specific ligand binding residues for novel agrochemical and drug design
(2015-01-01)
The term “agrochemicals” is used in its generic form to represent a spectrum of pesticides, such as insecticides, fungicides or bactericides. They contain active components designed for optimized pest management and control, ...
Molecular mechanism of peroxisome proliferator-activated receptor α activation by WY14643: a new mode of ligand recognition and receptor stabilization
(ElsevierAmsterdam, 2013-08)
Peroxisome proliferator-activated receptors (PPARs) are members of a superfamily of nuclear transcription factors. They are involved in mediating numerous physiological effects in humans, including glucose and lipid ...
Structure- and ligand-based drug design approaches for neglected tropical diseases
(INT UNION PURE APPLIED CHEMISTRYRES TRIANGLE PK, 2012)
Drug discovery has moved toward more rational strategies based on our increasing understanding of the fundamental principles of protein-ligand interactions. Structure( SBDD) and ligand-based drug design (LBDD) approaches ...
Novel N-arylsulfonylindoles targeted as ligands of the 5-HT6 receptor. Insights on the influence of C-5 substitution on ligand affinity
(MDPI, 2021)
A new series of twenty-two C-5 substituted N-arylsulfonylindoles was prepared with the aim of exploring the influence of C-5 substitution on 5-HT6 receptor affinity. Eleven compounds showed moderate to high affinity at the ...