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Design, synthesis and biological activity of novel substituted 3-benzoic acid derivatives as MtDHFR inhibitors
(Elsevier B.V., 2020-08-01)
The enzyme dihydrofolate reductase from M. tuberculosis (MtDHFR) has a high unexploited potential to be a target for new drugs against tuberculosis (TB), due to its importance for pathogen survival. Preliminary studies ...
Studies toward the structural optimization of novel thiazolylhydrazone-based potent antitrypanosomal agents
(PERGAMON-ELSEVIER SCIENCE LTD, 2010)
In previous studies, we identified promising anti-Trypanosoma cruzi cruzain inhibitors based on thiazolylhydrazones. To optimize this series, a number of medicinal chemistry directions were explored and new thiazolylhydrazones ...
Optimization of anti-Trypanosoma cruzi oxadiazoles leads to identification of compounds with efficacy in infected mice
(PERGAMON-ELSEVIER SCIENCE LTDOXFORD, 2012)
We recently showed that oxadiazoles have anti-Trypanosoma cruzi activity at micromolar concentrations. These compounds are easy to synthesize and show a number of clear and interpretable structure-activity relationships ...
Molecular Modeling And Structure-activity Relationships Studies Of Bioisoster Hybrids Of N-acylhydrazone And Furoxan Groups On Cruzain
(Springer BirkhauserNew York, 2017)