Now showing items 1-10 of 3856
Network approach identifies Pacer as an autophagy protein involved in ALS pathogenesis
BackgroundAmyotrophic lateral sclerosis (ALS) is a multifactorial fatal motoneuron disease without a cure. Ten percent of ALS cases can be pointed to a clear genetic cause, while the remaining 90% is classified as sporadic. ...
BioSmalltalk: a pure object system and library for bioinformatics
(Oxford University Press, 2013-09)
We have developed BioSmalltalk, a new environment system for pure object-oriented bioinformatics programming. Adaptive end-user programming systems tend to become more important for discovering biological knowledge, as is ...
A review of Bioinformatics training applied to research in Molecular Medicine, Agriculture and Biodiversity in Costa Rica and Central America
(Briefings in Bioinformatics, 14(5): 661-670, 2013-04-13)
Today, Bioinformatics has become a scientific discipline with great relevance for the Molecular Biosciences and for the Omics sciences in general. Although developed countries have progressed with large strides in ...
Computational Biology in Costa Rica: the role of a small country in the global context of bioinformatics
Introduction: The successful development of high throughput methods for DNA sequencing, transcriptomics, proteomics, and other –omics, has contributed to the emergence of novel possibilities for the examination of complex ...
Genome-wide circulating microRNA expression profiling reveals potential biomarkers for amyotrophic lateral sclerosis
(ELSEVIER SCIENCE INC, 2018)
The occurrence of mutations of TDP-43, FUS, and C9ORF72 in amyotrophic lateral sclerosis (ALS) suggests pathogenic alterations to RNA metabolism and specifically to microRNA (miRNA) biology. Moreover, several ALS-related ...
Nanoinformatics: an emerging area of information technology at the intersection of bioinformatics, computational chemistry and nanobiotechnology
(SOC BIOLGIA CHILE, 2011)
After the progress made during the genomics era, bioinformatics was tasked with supporting the fl ow of information generated by nanobiotechnology efforts. This challenge requires adapting classical bioinformatic and ...
NOTCH3 Gene Mutation in a Chilean Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy Family
Introduction: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a rare hereditary stroke disorder caused by mutations in the NOTCH3 gene. We report the first Chilean ...
Bioinformatic prediction of polymerase elements in the rotavirus VP1 protein
(Sociedad de Biología de Chile, 2006)
The past, present and future of genomics and bioinformatics: A survey of Brazilian scientists
(FapUNIFESP (SciELO), 2022-06)