In the Crigler–Najjar type I syndrome, the genetic absence of efficient hepatic glucuronidation of unconjugated bilirubin (UCB) by the uridine 5′-diphospho-glucuronosyltransferase1A1 (UGT1A1) enzyme produces the rise of ...

The determination of bilirubin is part of a basic panel of tests that assess liver function. Hyperbilirubinemia can occur due to defects in bilirubin metabolism resulting in jaundice, which can occur at each stage of the ...

Bilirubin is an endogenous antioxidant with cytoprotective properties, and several studies highlight its potential in the treatment of pro-oxidant diseases. We demonstrated that oxidative stress (OS), a key feature in most ...

Introduction In this study, we investigated if apical periodontitis (AP) associated with diabetes influenced the levels of endogenous antioxidants, the total antioxidant capacity (TAC), and the oxidant parameter in the ...

Nitric oxide (NO) is a reactive free radical, that acts as a messenger molecule, mediating several functions, including vasodilation, platelet aggregation inhibition, neurotransmission, antimicrobial and antitumor ...

The mechanisms responsible for the imbalance between oxidants and antioxidants in sheep infected with Haemonchus contortus are not well established. This study aimed to prove the hypothesis that oxidative stress occurring ...

We previously demonstrated in in vitro and ex vivo models that physiological concentrations of unconjugated bilirubin (BR) prevent oxidative stress (OS)-induced hepatocanalicular dysfunction and cholestasis. Here, we aimed ...