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Differential effects of beta 1 and beta 2 subunits on BK channel activity
(ROCKEFELLER UNIV PRESS, 2005-04)
High conductance, calcium- and voltage-activated potassium (BK) channels are widely expressed in mammals. In some tissues, the biophysical properties of BK channels are highly affected by coexpression of regulatory (beta) ...
Structural determinants for functional coupling between the beta and alpha subunits in the Ca2+-activated K+ (BK) channel
(ROCKEFELLER UNIV PRESS, 2006-02)
High conductance, calcium- and voltage-activated potassium (BK, MaxiK) channels are widely expressed in mammals. In some tissues, the biophysical properties of BK channels are highly affected by coexpression of regulatory ...
beta 1-subunit-induced structural rearrangements of the Ca2+- and voltage-activated K+ (BK) channel
(Natl Acad Sciences, 2016)
Large-conductance Ca2+- and voltage-activated K+ (BK) channels are involved in a large variety of physiological processes. Regulatory beta-subunits are one of the mechanisms responsible for creating BK channel diversity ...
Determination of the stoichiometry between alpha- and gamma 1 subunits of the BK channel using LRET
(Cell Press, 2018)
Two families of accessory proteins, beta and gamma, modulate BK channel gating and pharmacology. Notably, in the absence of internal Ca2+, the gamma 1 subunit promotes a large shift of the BK conductance-voltage curve to ...
Differential effects of beta 1 and beta 2 subunits on bk channel activity
(ROCKEFELLER UNIVERSITY PRESS, 2005)
Modulation of BK channel voltage gating by different auxiliary β subunits
(2012)
Calcium- and voltage-activated potassium channels (BK) are regulated by a multiplicity of signals. The prevailing view is that different BK gating mechanisms converge to determine channel opening and that these gating ...
Autoimmune reactivity against the 20S-proteasome includes immunosubunits LMP2 (beta 1i), MECL1 (beta 2i) and LMP7 (beta 5i)
(OXFORD UNIV PRESS, 2008)
Objectives. Autoantibodies against the 20S-proteasome display a broad diversity with a remarkably low frequency of individual cross-reactivity against the different subunits of the proteasome. Although their pathogenic and ...