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Identification of N-benzylacetamide as a major component of human plasmatic metabolic profiling of benznidazole
(Medecine Et Hygiene, 2014-04)
Chagas disease is an endemic infection in Latin America with a high health impact. Caused by the parasite Trypanosoma cruzi, it has expanded to non-endemic regions such as North America and European countries via immigration ...
Prevention of benznidazole-induced prolonging effect on the pentobarbital sleeping time of rats using different thiol-containing compounds
(PJD Publications, 2000-07)
Benznidazole (BZ) is a nitroimidazolic chemotherapeutic agent employed against the acute and indeterminate phase of Chagas' disease, a tropical sickness afflicting more than twenty million people in Latin America. BZ has ...
Benznidazole Biotransformation and Multiple Targets in Trypanosoma cruzi Revealed by Metabolomics
(Public Library Of Science, 2014-05)
Background
The first line treatment for Chagas disease, a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi, involves administration of benznidazole (Bzn). Bzn is a 2-nitroimidazole pro-drug ...
Benznidazole-induced ultrastructural and biochemical alterations in rat colon
(Wiley Blackwell Publishing, Inc, 2000-11)
AIM: To study the effects of benznidazole (Bz), a drug used in the chemotherapy of the acute and the intermediate phase of Chagas' disease, on the colon of rats.
METHODS: Sprague Dawley male rats received Bz 100 mg/kg ig. ...
Metodología UV para la determinación de los antichagásicos Nifurtimox y Benznidazol en sangreUV methodology for determination of antichagasic drugs Nifurtimox and Benznidazol in bloodMetodologia UV para a determinação dos antichagásicos Nifurtimox e Benznidazol em sangue
(Federación Bioquímica de la Provincia Buenos Aires, 2011-09)
El Mal de Chagas es una enfermedad parasitaria endémica en América del Sur y Central. Existen dos fármacos disponibles para el tratamiento médico de la enfermedad, el Nifurtimox (Nfx) y el Benznidazol (Bz). No existen ...
Development of UV/HPLC methods for quantitative analysis of benznidazole in human plasma and urine for application in pediatric clinical studies
(Wiley, 2013-09)
OBJECTIVE: Chagas disease constitutes a major public health problem in Latin America. Correctly designed pharmacokinetic, safety, and bioequivalence studies are desirable in order to fill the knowledge gaps that presently ...
Effect of chronic alcohol drinking on rat liver microsomal nitroreductive metabolism of Nifurtimox and Benznidazole
(Sage Publications Ltd, 2013-12)
Nifurtimox (Nfx) and benznidazole (Bz) have serious toxic side effects. Manufacturers warn about significant adverse effects when simultaneous alcohol consumption is being made, but its mechanism is not known. The levels ...