Buscar
Mostrando ítems 1-10 de 182
Benznidazole biotransformation in rat heart microsomal fraction without observable ultrastructural alterations: comparison to Nifurtimox-induced cardiac effects
(Fundação Oswaldo Cruz, 2008-09)
Benznidazole (Bz) and Nifurtimox (Nfx) have been used to treat Chagas’ disease. Recent studies evidenced cardiotoxic effects of Nfx. We attempted to test whether Bz behaves similarly. Bz reached heart tissue of male rats ...
Trypanosoma cruzi: In vitro effect of aspirin with nifurtimox and benznidazole
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2010)
Nifurtimox and benznidazole are the only active drugs against Trypanosoma cruzi; however, they have limited efficacy and severe side effects. During primoinfection, T cruzi infected macrophages mount an antiparasitic ...
Effects of buthionine sulfoximine nifurtimox and benznidazole upon trypanothione and metallothionein proteins in Trypanosoma cruzi
(Society of Biology of Chile, 2004)
Proteins rich in sulfhydryl groups, such as metallothionein, are present in several strains of the parasite Trypanosoma cruzi, the etiological agent of Chagas' disease. Metallothionein-like protein concentrations ranged ...
Effects of buthionine sulfoximine nifurtimox and benznidazole upon trypanothione and metallothionein proteins in Trypanosoma cruzi.
(Sociedad de Biología de Chile, 2004)
Nanocarriers for effective delivery of benznidazole and nifurtimox in the treatment of chagas disease: A review
(Elsevier Science, 2019-10)
Neglected tropical diseases (NTDs) constitute a group of infectious diseases prevalent in countries with tropical and subtropical climate that affect the poorest individuals and produce high chronic disability associated ...
Trypanosoma cruzi: In vitro effect of aspirin with nifurtimox and benznidazole
(ELSEVIER, 2010)
Nifurtimox and benznidazole are the only active drugs against Trypanosoma cruzi; however, they have
limited efficacy and severe side effects. During primoinfection, T. cruzi infected macrophages mount an
antiparasitic ...
Effect of chronic alcohol drinking on rat liver microsomal nitroreductive metabolism of Nifurtimox and Benznidazole
(Sage Publications Ltd, 2013-12)
Nifurtimox (Nfx) and benznidazole (Bz) have serious toxic side effects. Manufacturers warn about significant adverse effects when simultaneous alcohol consumption is being made, but its mechanism is not known. The levels ...
Current drug therapy and pharmaceutical challenges for Chagas disease
(Elsevier Science, 2016-04)
One of the most significant health problems in the American continent in terms of human health, and socioeconomic impact is Chagas disease, caused by the protozoan parasite Trypanosoma cruzi. Infection was originally ...
Old yellow enzyme from Trypanosoma cruzi exhibits in vivo prostaglandin F-2 alpha synthase activity and has a key role in parasite infection and drug susceptibility
(Frontiers media SA, 2018)
The discovery that trypanosomatids, unicellular organisms of the order Kinetoplastida, are capable of synthesizing prostaglandins raised questions about the role of these molecules during parasitic infections. Multiple ...