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Early ethanol pre-exposure alters breathing patterns by disruptions in the central respiratory network and serotonergic balance in neonate rats
(Elsevier Science, 2021-01)
Early ethanol exposure alters neonatal breathing plasticity. Respiratory EtOH's effects are attributed to central respiratory network disruptions, particularly in the medullary serotonin (5HT) system. In this study we ...
Neonatal sensitization to ethanol-induced breathing disruptions as a function of late prenatal exposure to the drug in the rat: Modulatory effects of ethanol's chemosensory cues
(Pergamon-Elsevier Science Ltd, 2015-02)
Preclinical and clinical studies have systematically demonstrated abrupt changes in fetal respiratory patterns when the unborn organism is exposed to the effects of maternal ethanol intoxication. In subprimates, chronic ...
Early Ethanol Preexposure Modifies Expression of the 5HT2A Receptor Promoting Long-Term Breathing Plasticity in Neonate Rats
(SAGE Publications, 2019)
EtOH´s effects upon respiration are attributed to central respiratory network disruptions, especially in the medullary serotonin (5HT) system. 5HT2A/2C receptors are involved in the reduction of the phrenic nerve activity ...
Neonatal experiences with ethanol intoxication modify respiratory and thermoregulatory plasticity and affect subsequent ethanol intake in rats
(John Wiley & Sons Inc, 2017-01-19)
Different studies have focused on the deleterious consequences of binge-like or chronic exposure to ethanol during the brain growth spurt period (third human gestational trimester) that in the rat corresponds to postnatal ...
Facilitation of breathing by leptin effects in the central nervous system
(2015)
With the global epidemic of obesity, breathing disorders associated with excess body weight have markedly increased. Respiratory dysfunctions caused by obesity were originally attributed to mechanical factors; however, ...
Conditioned breathing depression during neonatal life as a function of associating ethanol odor and the drug's intoxicating effects
(John Wiley & Sons Inc, 2016-09)
Fetal and neonatal ethanol-related alterations upon the respiratory system have been described in different mammals. Studies also indicate that perinates learn about the sensory attributes of ethanol and associate them ...
Hypercapnic and Hypoxic Respiratory Response during Wakefulness and Sleep in a Streptozotocin Model of Alzheimer's Disease in Rats
(2018-01-01)
Besides the typical cognitive decline, patients with Alzheimer's disease (AD) develop disorders of the respiratory system, such as sleep apnea, shortness of breath, and arrhythmias. These symptoms are aggravated with the ...
Serotonin and the control of eupneic breathing
(2018-01-01)
The mechanisms responsible for respiratory rhythm and pattern generation are continuously tuned by neuromodulators. Serotonin is a powerful modulator of the respiratory network that regulates synaptic and intrinsic properties ...