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Therapeutic opportunities for PLK1 inhibitors: Spotlight on BRCA1-deficiency and triple negative breast cancers
(Elsevier Science, 2020-05)
Polo-Like Kinases (PLKs) are central players of mitotic progression in Eukaryotes. Given the intimate relationship between cell cycle progression and cancer development, PLKs in general and PLK1 in particular have been ...
Polo-like kinase 1 inhibition as a therapeutic approach to selectively target BRCA1-deficient cancer cells by synthetic lethality induction
(American Association for Cancer Research, 2019-03)
Purpose: BRCA1 and BRCA2 deficiencies are widespread drivers of human cancers that await the development of targeted therapies. We aimed to identify novel synthetic lethal relationships with therapeutic potential using ...
Persistent double strand break accumulation does not precede cell death in an olaparib-sensitive BRCA-deficient colorectal cancer cell model
(Sociedade Brasileira de Genética, 2019-12-13)
The poly (adenosine diphosphate (ADP)-ribosyl) polymerase inhibitors (PARPi) selectively kill cancer cells with BRCA1 or BRCA2 (BRCA)-mutations. It has been proposed that cell death induction after PARPi depends on unrepaired ...
Different Array CGH profiles within hereditary breast cancer tumors associated to BRCA1 expression and overall survival
(2016)
Abstract
Background
Array CGH analysis of breast tumors has contributed to the identification of different genomic profiles in these tumors. Loss of DNA repair by BRCA1 ...
Synthetic lethal activity of benzophenanthridine alkaloids from Zanthoxylum coco against BRCA1-deficientcancer cells
(Frontiers Media S.A., 2020-12)
Several plants from South America show strong antitumoral properties based on anti-proliferative and/or pro-apoptotic activities. In this work we aimed to identify selective cytotoxic compounds that target BRCA1-deficient ...
Different Array CGH profiles within hereditary breast cancer tumors associated to BRCA1 expression and overall survival
(2016)
Background:Array CGH analysis of breast tumors has contributed to the identification of different genomic profiles in these tumors. Loss of DNA repair by BRCA1 functional deficiency in breast cancer has been proposed as a ...
Different Array CGH profiles within hereditary FFPE breast cancer tumors associated to BRCA1 expression and overall survival
(2016)
BackgroundArray CGH analysis of breast tumors has contributed to the identification of different genomic profiles in these tumors. Loss of DNA repair by BRCA1 functional deficiency in breast cancer has been proposed as a ...
Different Array CGH profiles within hereditary breast cancer tumors associated to BRCA1 expression and overall survival
(BioMed Central Ltd., 2016)
© 2016 Alvarez et al.Background: Array CGH analysis of breast tumors has contributed to the identification of different genomic profiles in these tumors. Loss of DNA repair by BRCA1 functional deficiency in breast cancer ...