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Early estradiol exposure masculinizes disease-relevant behaviors in female mice
(Wiley Blackwell Publishing, Inc, 2021-04)
Most psychiatric disorders show a sex bias in incidence, symptomatology, and/or response to treatment. Males are more susceptible to neurodevelopmental disorders including autism spectrum disorder and attention-deficit ...
Prenatal Lipopolysaccharide Exposure Affects Maternal Behavior and Male Offspring Sexual Behavior in Adulthood
(KARGER, 2010)
Objective: This study investigates the effects of prenatal lipopolysaccharide (LPS) exposure on the maternal behavior of pregnant rats and the physical development and sexual behavior of their male offspring in adulthood. ...
Maternal exposure to ibuprofen can affect the programming of the hypothalamus of the male offspring
(2020-03-01)
Ibuprofen, a non-steroidal anti-inflammatory drug, inhibits the activity of cyclooxygenase enzyme, leading to reduction in Prostaglandin E2 (PGE2) production. Due to the importance of PGE2 in promoting the brain masculinization ...
Histone deacetylase gene expression is regulated by sex chromosome complement in the amygdala of the developing mouse brain
(2020)
Sexual differentiation of the rodent brain depends mainly on the action of androgens secreted by the fetal testis during the perinatal critical period (E17-P10). Recently, the role of genetic factors derived from sex ...
Lactational exposure to venlafaxine provokes late repercussions on reproductive parameters in male rat offspring
(Wiley-Blackwell, 2022-09-10)
Exposure to selective serotonin reuptake inhibitors can affect hormone-dependent processes, such as the brain sexual differentiation. Because the use of these antidepressants cause concern during lactation, we evaluated ...
The central nervous system acts as a transducer of stress-induced masculinization through corticotropin-releasing hormone b
(Company of Biologists, 2019-04)
Exposure to environmental stressors, like high temperature (HT), during early development of fish induces sex reversal of genotypic females. Nevertheless, the involvement of the brain in this process is not well clarified. ...
Perinatal programming of the orexinergic (hypocretinergic) system in hypothalamus and anterior pituitary by testosterone
(Elsevier Inc, 2018-01)
Orexins A/B derived from hypothalamic prepro-orexin (PPO) are agonists for orexin receptors 1 (OX1) and 2 (OX2). Previously, we showed clear sex differences in the hypothalamic-pituitary-gonadal orexinergic system in adult ...
Programming of the reproductive axis by hormonal and genetic manipulation in mice
(BioScientifica, 2018-06)
In mammals, the reproductive function is controlled by the hypothalamic-pituitary-gonadal axis. During development, mechanisms mediated by gonadal steroids exert an imprinting at the hypothalamic-pituitary level, by ...
Developmental changes and sex differences in DNA methylation and demethylation in hypothalamic regions of the mouse brain
(Landes Bioscience, 2019-08)
DNA methylation is dynamically modulated during postnatal brain development, and plays a key role in neuronal lineage commitment. This epigenetic mark has also recently been implicated in the development of neural sex ...
Neonatal inhalatory anesthetic exposure: Reproductive changes in male rats
(2002-12-01)
We investigated the effects of an inhalatory anesthetic (ethyl ether) during the neonatal period of brain sexual differentiation on the later fertility and sexual behavior of male rats. Animals were exposed to ethyl ether ...