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AGK-BRAF gene fusion is a recurrent event in sporadic pediatric thyroid carcinoma
(Wiley-Blackwell, 2016)
Thyroid cancer is the fastest increasing cancer worldwide in all age groups. Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer in both adults and children. PTC genomic landscape has been extensively ...
Lack of association between BRAF mutation and MAPK ERK activation in melanocytic nevi
(NATURE PUBLISHING GROUP, 2006)
The mitogen-activated protein kinase (MAPK) extracellular signal-regulated kinase signaling pathway can be activated through mutations of V-RAF murine sarcoma viral oncogene homolog B1 (BRAF) oncogene, frequently found in ...
Status de mutação BRAF p.V600E em diferentes áreas microscópicas do ameloblastoma
(Universidade Federal de Minas GeraisBrasilFAO - FACULDADE DE ODONTOLOGIAPrograma de Pós-Graduação em OdontologiaUFMG, 2020-07-21)
BRAF p.V600E is the most common mutation in conventional ameloblastomas and unicystic ameloblastomas. It is known that odontogenic cysts do not present this mutation and that they represent an important differential diagnosis ...
Avaliação da heterogeneidade intratumoral e intermetástases do éxon 15 do gene braf (7q34) em amostras de melanoma metastático
(Universidade Federal de São Paulo (UNIFESP), 2015-06-05)
Introduction: Approximately a half of cutaneous melanoma has a BRAF V600E mutation and benefits from treatment with BRAF and MEK inhibitors, showing rapid tumor regression. However, most of these patients had progression ...
High Prevalence of BRAF Mutation in a Brazilian Cohort of Patients With Sporadic Papillary Thyroid Carcinomas Correlation With More Aggressive Phenotype and Decreased Expression of Iodide-Metabolizing Genes
(Wiley-Blackwell, 2009-03-01)
BACKGROUND: Although several studies undoubtedly demonstrated that BRAF mutation is an important genetic event in the pathogenesis of papillary thyroid carcinoma (PTC), its prognostic significance and correlation with less ...
Seven-year follow-up of a juvenile female with papillary thyroid carcinoma with poor outcome, BRAF mutation and loss of expression of iodine-metabolizing genes
(Sociedade Brasileira de Endocrinologia e Metabologia, 2008-11-01)
BACKGROUND: Recent studies reported that BRAF V600E mutation, the most prevalent genetic event found in papillary thyroid carcinoma, is an independent poor prognostic marker. Additionally, it correlates with a less ...
Braf-v600e Expression Correlates With Ameloblastoma Aggressiveness
(Wiley-BlackwellHoboken, 2017)
Current concepts in ameloblastoma-targeted therapies in B-raf proto-oncogene serine/threonine kinase V600E mutation: Systematic review
(2020)
Ameloblastomas are common benign epithelial odontogenic neoplasms that
present an aggressive and unpredictable behavior that may modify treatment
strategies. Different signaling pathways that participate in the progression ...
Mutación del gen BRAF en pacientes con cánceres de colon y recto con KRAS no mutado
(Sociedad Médica de Santiago, 2014)
Background: In colorectal cancer, BRAF and KRAS mutation are mutually
exclusive, but both are independent prognostic factors for the disease. Aim: To
determine the frequency of BRAF V600E mutation in colorectal cancer. ...