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Early effect of boron neutron capture therapy mediated by boronophenylalanine (BPA-BNCT) on mast cells in premalignant tissue and tumors of the hamster cheek pouch
(Elsevier Science, 2010-05)
Mast cell (MC) activation in the hamster cheek pouch cancerization model is associated with the increase in tumor cell proliferation, mediated in turn by tryptase, a protease released from mast cell granules after activation. ...
Kohonen classification applying 'missing variables' criterion to evaluate the p-boronophenylalanine human-body-concentration decreasing profile of boron neutron capture therapy patients
(John Wiley & Sons Ltd, 2011-06)
The irradiation dose in tumor and healthy tissue of a boron neutron capture therapy (BNCT) patient depends on the boron concentration in blood. In most treatments, this concentration is experimentally determined before and ...
Boron uptake in normal melanocytes and melanoma cells and boron biodistribution study in mice bearing B16F10 melanoma for boron neutron capture therapy
(SPRINGERNEW YORK, 2012)
Information on B-10 distribution in normal tissues is crucial to any further development of boron neutron capture therapy (BNCT). The goal of this study was to investigate the in vitro and in vivo boron biodistribution in ...
Boron neutron capture synovectomy (BNCS) as a potential therapy for rheumatoid arthritis: radiobiological studies at RA-1 Nuclear Reactor in a model of antigen-induced arthritis in rabbits
(Springer, 2016-09)
Rheumatoid arthritis is a chronic autoimmune pathology characterized by the proliferation and inflammation of the synovium. Boron neutron capture synovectomy (BNCS), a binary treatment modality that combines the preferential ...
Biodistribution of the boron carriers boronophenylalanine (BPA) and/or decahydrodecaborate (GB-10) for Boron Neutron Capture Therapy (BNCT) in an experimental model of lung metastases
(Elsevier, 2013-12)
BNCT was proposed for the treatment of diffuse, non-resectable tumors in the lung. We performed boron biodistribution studies with 5 administration protocols employing the boron carriers BPA and/or GB-10 in an experimental ...
Experimental studies of boronophenylalanine (10BPA) biodistribution for the individually tailored application of boron neutron capture therapy (BNCT) for malignant melanoma treatment
(Elsevier Science Inc, 2015-05)
Purpose: Patients with the same histopathologic diagnosis of cutaneous melanoma treated with identical protocols of boron neutron capture therapy (BNCT) have shown different clinical outcomes. The objective of the present ...
Histamine reduces boron neutron capture therapy‐induced mucositis in an oral precancer model
(Wiley Blackwell Publishing, Inc, 2015-09)
Objectives: Searching for more effective and selective therapies for head and neck cancer, we demonstrated the therapeutic effect of boron neutron capture therapy (BNCT) to treat oral cancer and inhibit long-term tumor ...
Artificial neural networks to evaluate the boron concentration decreasing profile in Blood-BPA samples of BNCT patients
(Pergamon-Elsevier Science Ltd, 2011-12)
For the prediction of decay concentration profiles of the p-boronophenylalanine (BPA) in blood during BNCT treatment, a method is suggested based on Kohonen neural networks. The results of a model trained with the concentration ...
Neutron autoradiography to study boron compound microdistribution in an oral cancer model
(Taylor & Francis Ltd, 2015-04)
Purpose : We previously reported the therapeutic effi cacy of Sequential Boron Neutron Capture Therapy (Seq-BNCT), i.e., BPA (boronophenylalanine) ? BNCT followed by GB-10 (decahydrodecaborate) ? BNCT 1 or 2 days later, ...