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Synergism of arsenic trioxide and MG132 in Raji cells attained by targeting BNIP3, autophagy, and mitochondria with low doses of valproic acid and vincristine
(Elsevier, 2014-10)
We previously demonstrated that arsenic trioxide (ATO) and proteasome inhibitor MG132 synergistically induced cell death in promonocytic leukaemia cell line U937 but were antagonistic in Burkitt’s lymphoma cell line Raji. ...
Targeting mitophagy in combined therapies of haematological malignancies
(IntechOpen, 2016)
Mitophagy is a selective form of autophagy that eliminates mitochondria, and ispart of a larger network of mitochondrial quality control processes that respond tomitochondrial damage. Treatment of haematological malignancies ...
Bnip3l In Myelodysplastic Syndromes And Acute Myeloid Leukemia: Impact On Disease Outcome And Cellular Response To Decitabine
(Ferrata Storti FoundationPavia, 2016)
Blocking drug-induced autophagy with chloroquine in HCT-116 colon cancer cells enhances DC maturation and T cell responses induced by tumor cell lysate
(2020-07-01)
Autophagy is an important mechanism for tumor escape, allowing tumor cells to recover from the damage induced by chemotherapy, radiation therapy, and immunotherapy and contributing to the development of resistance. The ...
Autophagy signaling in skeletal muscle of infarcted rats
(San Francisco, CA, 2014)
Background: Heart failure (HF)-induced skeletal muscle atrophy is often associated to exercise intolerance and poor prognosis. Better understanding of the molecular mechanisms underlying HF-induced muscle atrophy may ...
Estudio de la mitofagia en respuesta a un programa de entrenamiento de fuerza en personas mayores
(Universidad de LeónExternas/Outras Instituições, 2022)
Moderate, but not excessive, training attenuates autophagy machinery in metabolic tissues
(2020-11-02)
The protective effects of chronic moderate exercise-mediated autophagy include the prevention and treatment of several diseases and the extension of lifespan. In addition, physical exercise may impair cellular structures, ...
Citotoxicidad por efecto del insecticida piretroide flumetrín sobre el estatus oxidativo, proinflamación y apoptosis en células neuronales SH-SY5Y
(Universidad Nacional Mayor de San MarcosPE, 2022)
Evalua la citotoxicidad e inducción de estrés oxidativo, proinflamación y apoptosis en células de neuroblastoma humano SH‑SY5Y expuestas a flumetrín. Los ensayos de viabilidad celular (ensayo de MTT) y de lactato deshidrogenasa ...