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Low Doses of Glyphosate/Roundup Alter Blood–Testis Barrier Integrity in Juvenile Rats
(Frontiers Media, 2021-03)
It has been postulated that glyphosate (G) or its commercial formulation Roundup (R) might lead to male fertility impairment. In this study, we investigated the possible effects of G or R treatment of juvenile male rats ...
Regulatory and junctional proteins of the blood-testis barrier in human Sertoli cells are modified by monobutyl phthalate (MBP) and bisphenol A (BPA) exposure
(2016-08-01)
The blood-testis barrier (BTB) is responsible for providing a protected environment and coordinating the spermatogenesis. Endocrine disruptors (EDs) might lead to infertility, interfering in the BTB structure and modulation. ...
IL17A impairs blood-testis barrier integrity and induces testicular inflammation
(Springer, 2014-09)
Experimental autoimmune orchitis is a useful model for studying testicular inflammation and germ/immune cell interactions. Th17 cells and their hallmark cytokine IL17A were reported to be involved in the development of ...
Dual role of immune cells in the testis: protective or pathogenic for germ cells?
(Taylor & Francis, 2013-01)
The purpose of this review is to describe how the immune cells present in the testis interact with the germinal epithelium contributing to survival or apoptosis of germ cells (GCs). Physiologically, the immunosuppressor ...
Cadmium-induced testicular injury
(Elsevier B.V., 2009-08-01)
Cadmium (Cd) is an environmental toxicant and an endocrine disrupter in humans and rodents. Several organs (e.g., kidney, liver) are affected by Cd and recent studies have illustrated that the testis is exceedingly sensitive ...
What do we know about blood-testis barrier? current understanding of its structure and physiology
(Frontiers Media SA, 2024)
Importance of the Androgen Receptor Signaling in Gene Transactivation and Transrepression for Pubertal Maturation of the Testis
(Multidisciplinary Digital Publishing Institute, 2019-08-09)
Androgens are key for pubertal development of the mammalian testis, a phenomenon that is tightly linked to Sertoli cell maturation. In this review, we discuss how androgen signaling affects Sertoli cell function and ...
Experimental autoimmune orchitis as a model of immunological male infertility
(Springer Tokyo, 2012-12)
Clinically, 60-75% of male infertility cases are categorized as idiopathic spermatogenic disturbance. In previous studies of this condition, lymphocytic infiltration and immune deposits were present in several testis biopsy ...
Loss of Occludin Expression and Impairment of Blood-Testis Barrier Permeability in Rats with Autoimmune Orchitis: Effect of Interleukin 6 on Sertoli Cell Tight Junctions
(Society for the Study of Reproduction, 2012-11)
Inflammation of the male reproductive tract is accepted as being an important etiological factor of infertility. Experimental autoimmune orchitis (EAO) is characterized by interstitial lymphomononuclear cell infiltration ...
Cell junctions in fish seminiferous epithelium
(2009-01-01)
Similar to mammals, in fish the cellular interactions between Sertoli cells (SC) and germ cells (GC) in the seminiferous epithelium have important structural and functional roles. In this review, we give a brief summary ...