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Marked bleeding diathesis in patients with platelet dysfunction due to a novel mutation in RASGRP2, encoding CalDAG-GEFI (p.Gly305Asp)
(Taylor & Francis Ltd, 2018-01)
Congenital platelet function disorders are often the result of defects in critical signal transduction pathways required for platelet adhesion and clot formation. Mutations affecting RASGRP2, the gene encoding the Rap ...
Bleeding diathesis in patients with chronic myelogenous leukemia receiving dasatinib therapy
(American Cancer SocietyPE, 2009-06-01)
Antecedentes: Los efectos secundarios no hematológicos más frecuentes asociados con el tratamiento con dasatinib en pacientes con leucemia mieloide crónica (LMC) son síndromes gastrointestinales, erupción cutánea y retención ...
Platelet membrane glycoprotein polymorphisms do not influence the clinical expressivity of von Willebrand disease type I
(SCHATTAUER GMBH-VERLAG MEDIZIN NATURWISSENSCHAFTEN, 2003)
Von Willebrand disease (VWD) is characterized by a significant variation in bleeding symptoms among patients with similar laboratory profiles and equivalent plasma levels of von Willebrand factor (VWF) activities. Considering ...
Validation of the ISTH/SSC bleeding assessment tool for inherited platelet disorders: a communication from the Platelet Physiology SSC
(Wiley Blackwell Publishing, Inc, 2019-12)
Background: Careful assessment of bleeding history is the first step in the evaluation of patients with mild/moderate bleeding disorders, and the use of a bleeding assessment tool (BAT) is strongly encouraged. Although a ...
Portal vein thrombosis following laparoscopic cholecystectomy complicated by dengue viral infection: a case report
(2011-03-30)
Abstract Introduction Portal vein thrombosis is an uncommon post-operative complication following abdominal surgery. Although therapeutic anticoagulation is recommended, this treatment may be questionable when the patient ...
Platelets as mediators of Thromboinflammation in chronic Myeloproliferative Neoplasms
(Frontiers Research Foundation, 2019-06-14)
Chronic myeloproliferative neoplasms (MPN) are stem cell disorders driven by mutations in JAK2, CALR, or MPL genes and characterized by myeloid proliferation and increased blood cell counts. They encompass three closely ...
Coagulation abnormalities in acute promyelocytic leukemia
(Associação Brasileira de Hematologia e Hemoterapia e daSociedade Brasileira de Transplante de Medula Óssea, 2009)
Acute promyelocytic leukemia is frequently accompanied by coagulation abnormalities usually described as laboratorial disseminated intravascular coagulation, which is the main cause of morbidity and early mortality. Aberrant ...
Manifestations related to alterations in coagulation in systemic lupus erythematosus of juvenile onset. Case report and literature review
Haematological alterations are common in patients with systemic lupus erythematosus (SLE). These haematological manifestations may be expressed related to the involvement of cells affected and coagulation changes. The ...
Prothrombin levels in yellow feverProthrombin levels in yellow fever
(Universidad de Costa Rica, 1954)
Methionine-induced hyperhomocysteinemia reverts fibrinolytic pathway activation in a murine model of acute promyelocytic leukemia
(AMER SOC HEMATOLOGYWASHINGTON, 2012)
Increased fibrinolysis is an important component of acute promyelocytic leukemia (APL) bleeding diathesis. APL blasts overexpress annexin II (ANXII), a receptor for tissue plasminogen activator (tPA), and plasminogen, ...