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Second-order sliding mode observer for multiple kinetic rates estimation in bioprocesses
(Elsevier, 2013-09)
Specific kinetic rates are key variables regarding metabolic activity in bioprocesses. They are non-linear functions of concentrations and operating conditions and therefore of difficult access for process control. In this ...
Sufficient conditions for state observability in multi-substrate bioprocesses with additive growth dynamics
(Institute of Electrical and Electronics Engineers, 2014-07)
The distinguishability of the non-measured states is relevant for the design and implementation of state observers. The aim of this study is to examine the observability of a fed-batch multi-substrate process with additive ...
Reaction rate reconstruction from biomass concentration measurement in bioreactors using modified second-order sliding mode algorithms
(Springer, 2012-11)
This paper deals with the estimation of unknown signals in bioreactors using sliding observers. Particular attention is drawn to estimate the specific growth rate of microorganisms frommeasurement of biomass concentration. ...
Modelling and optimization of the cephalosporin C production bioprocess in a fed-batch bioreactor with invert sugar as substrate
(Elsevier B.V., 1999-08-01)
Cephalosporin C production process optimization was studied based on four experiments carried out in an agitated and aerated tank fermenter operated as a fed-batch reactor. The microorganism Cephalosporium acremonium ATCC ...
Modelling and optimization of the cephalosporin C production bioprocess in a fed-batch bioreactor with invert sugar as substrate
(Elsevier B.V., 1999-08-01)
Cephalosporin C production process optimization was studied based on four experiments carried out in an agitated and aerated tank fermenter operated as a fed-batch reactor. The microorganism Cephalosporium acremonium ATCC ...
Robust nonlinear observers for bioprocesses: Application to wastewater treatment
(2007)
In this chapter, some state estimation schemes used in bioprocesses engineering are firstly reviewed with particular emphasis on the so-called nonlinear observers. Second, two simple robust nonlinear observers are proposed ...
Multivariable Control for Tracking Optimal Profiles in a Nonlinear Fed-Batch Bioprocess Integrated with State Estimation
(American Chemical Society, 2017-05)
This paper aims to solve the problem of tracking optimal profiles for a nonlinear multivariable fed-batch bioprocess by a simple but efficient closed-loop control technique based on a linear algebra approach. In the proposed ...
Product-based sliding mode observer for biomass and growth rate estimation in Luedeking-Piret like processes
(Institution of Chemical Engineers, 2016-01)
The on-line estimation of non-measurable substances and key process variables is relevant for the real-time monitoring of the bioprocesses. This paper deals with the on-line estimation of microbial growth rate and biomass ...