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L-asparaginase production review: bioprocess design and biochemical characteristics
(2021-06-01)
Abstract: In the past decades, the production of biopharmaceuticals has gained high interest due to its great sensitivity, specificity, and lower risk of negative effects to patients. Biopharmaceuticals are mostly therapeutic ...
Polymorphic and quantum chemistry characterization of candesartan cilexetil: importance for the correct drug classification according to biopharmaceutics classification system
(Universidade Federal de Minas GeraisBrasilICX - DEPARTAMENTO DE QUÍMICAUFMG, 2018-10)
Preparation, physicochemical and biopharmaceutical characterization of oxcarbazepine-loaded nanostructured lipid carriers as potential antiepileptic devices
(Editions Sante, 2021-06)
Epilepsy is the second most common chronic central nervous system disorder. Oxcarbazepine (OXC) is an antiepileptic drug with low solubility in aqueous media but is used for the treatment of both focal and generalized ...
Development of a workflow for therapeutic antibody characterization by LC-MS/MS
(Fiocruz/Instituto de Tecnologia em Imunobiológicos, 2023)
Standardization and optimization of electrophoretic methods for the analysis of homogeneity and physicochemical characterization of recombinant human erythropoietin
(Fiocruz/Instituto de Tecnologia em Imunobiológicos, 2018)
Furosemide:Triethanolamine Salt as a Strategy to Improve the Biopharmaceutical Properties and Photostability of the Drug
(American Chemical Society, 2019-04)
With the purpose of enhancing the biopharmaceutical properties of the furosemide, a pharmaceutical salt was obtained and characterized by combining the drug and triethanolamine. The solid system was prepared using different ...
Biopharmaceutical and antifungal properties of ellagic acid-cyclodextrin using an in vitro model of invasive candidiasis
(2019-01-01)
Aim: To investigate biopharmaceutical and antifungal properties of pure and complexed ellagic acid. Materials & methods: Caco-2 cells cultured in a Transwell® inserts were infected with Candida albicans to develop an in ...
Characterization of systems with amino-acids and oligosaccharides as modifiers of biopharmaceutical properties of furosemide
(Elsevier Science, 2018-02)
Furosemide is the most commonly prescribed diuretic drug in spite of its suboptimal biopharmaceutical properties. In this work, the addition of different amino-acids was studied with the aim of selecting an enhancer of the ...