Brain Derived Neurotrophic Factor (BDNF) is broadly express in many circuits of the central nervous system (CNS) and binds its receptors TrkB and p75. BDNF triggers different signaling pathways, including the kinases ERK1/2, ...

The brain-derived neurotrophic factor, BDNF, was discovered more than 30 years ago and, like other members of the neurotrophin family, this neuropeptide is synthetized as a proneurotrophin, the pro-BDNF, which is further ...

A wealth of evidence suggests a role for brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-related kinase B (TrkB) in the aetiology of depression and in the mode of action of antidepressant drugs. Less ...

Lipopolysaccharide (LPS) has been long known to promote neuroinflammation and disrupting memory pathway and neurogenesis. Since spermine, one of the main natural polyamines in the central nervous system, protects from LPS ...

Brain-derived neurotrophic factor (BDNF) and its receptors TrkB and p75 regulate dendritic and axonal growth during development and maintenance of the mature nervous system; however, the cellular and molecular mechanisms ...

Even though many extracellular factors have been identified as promoters of general dendritic growth and branching, little is known about the cell-intrinsic modulators that allow neurons to sculpt distinctive patterns of ...

Depression is considered a public health challenge around the world. According to the World Health Organization, more than 300 million people (approximately 6% of the world population) are affected by this disorder. ...