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mechanisms of long-distance control of dendritic growth by brain-derived neurotrophic factor (BDNF) in central neurons
(2019)
Brain Derived Neurotrophic Factor (BDNF) is broadly express in many circuits of the central nervous system (CNS) and binds its receptors TrkB and p75. BDNF triggers different signaling pathways, including the kinases ERK1/2, ...
BDNF isoforms: a round trip ticket between neurogenesis and serotonin?
(Wiley, 2016-07)
The brain-derived neurotrophic factor, BDNF, was discovered more than 30 years ago and, like other members of the neurotrophin family, this neuropeptide is synthetized as a proneurotrophin, the pro-BDNF, which is further ...
Panicolytic-like effect of BDNF in the rat dorsal periaqueductal grey matter: the role of 5-HT and GABA
(CAMBRIDGE UNIV PRESS, 2010)
A wealth of evidence suggests a role for brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-related kinase B (TrkB) in the aetiology of depression and in the mode of action of antidepressant drugs. Less ...
O efeito neuroprotetor da Espermina em condições de inflamação ocorre via BDNF, ativação do receptor TrkB, CREB e alteração na neurogênese
(Universidade Federal de Santa MariaBrasilFarmacologiaUFSMPrograma de Pós-Graduação em FarmacologiaCentro de Ciências da Saúde, 2019-06-11)
Lipopolysaccharide (LPS) has been long known to promote neuroinflammation and disrupting memory pathway and neurogenesis. Since spermine, one of the main natural polyamines in the central nervous system, protects from LPS ...
Cellular and molecular mechanisms regulating neuronal growth by brain-derived neurotrophic factor
(Wiley, 2016)
Brain-derived neurotrophic factor (BDNF) and its receptors TrkB and p75 regulate dendritic and axonal growth during development and maintenance of the mature nervous system; however, the cellular and molecular mechanisms ...
Lrig1 is a cell-intrinsic modulator of hippocampal dendrite complexity and BDNF signaling
(Nature Publishing Group, 2016-04)
Even though many extracellular factors have been identified as promoters of general dendritic growth and branching, little is known about the cell-intrinsic modulators that allow neurons to sculpt distinctive patterns of ...
Depressão: aspectos fisiopatológicos e o efeito tipo-antidepressivo da apocinina
(Universidade Federal de Santa MariaBrasilFarmacologiaUFSMPrograma de Pós-Graduação em FarmacologiaCentro de Ciências da Saúde, 2020-02-17)
Depression is considered a public health challenge around the world. According to the World Health Organization, more than 300 million people (approximately 6% of the world population) are affected by this disorder. ...