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Domino reactions with 5-azido- and 5-amino-4- trifluoromethyl-1,3-azoles.
(Sociedad Química del Perú, 2005)
Characterization of azole resistance mechanisms in chilean clinical isolates of Candida albicans Caracterización de los mecanismos de resistencia a azoles en aislados clínicos chilenos de Candida albicans
(Sociedad Chilena de Infectologia, 2014)
© 2014 Sociedad Chilena de Infectologia. All rights reserved. Abstract Introduction: The commensal yeast Candida albicans, can cause superficial or systemic candidiasis in susceptible hosts. In Chile, azole antifungals are ...
Hologram- and descriptor-based QSAR studies for a series of non-azoles derivatives active against C. neoformans
(Brasil, 2013)
Over the last decades fungal infections have become an increasing health problem, especially for immunocompromised patients. Unfortunately, the gold standard prophylactic therapy for such ailment is based on azole derivatives, ...
An azole tolerant endosomal trafficking mutant of Candida albicans is susceptible to azole treatment in a mouse model of vaginal candidiasis.
(Estados Unidos Antimicrobial Agents and Chemotherapy, 2017., 2019-09-24)
We recently reported that a Candida albicans endosomal trafficking mutant continues to grow after treatment with the azole antifungals. Herein, we report that the vps21Δ/Δ mutant does not have a survival advantage over ...
2D chemometric studies of a series of azole derivatives active against fluconazole-resistant Cryptococcus gattii
(Brasil, 2013)
Despite advances in the development of antifungal drugs,there has been an upsurge of cryptococosis infections that poorly respond to fluconazole (first choice drug). Hence,it is paramount to investigate the chemical ...
Requirement for Ergosterol in V-ATPase Function Underlies Antifungal Activity of Azole Drugs
(Public Library of Science, 2010-06)
Ergosterol is an important constituent of fungal membranes. Azoles inhibit ergosterol biosynthesis, although the cellular basis for their antifungal activity is not understood. We used multiple approaches to demonstrate a ...