Buscar
Mostrando ítems 1-10 de 196
Response to azolic antifungal agents for treating feline sporotrichosis
(British Veterinary Medicine, 2019)
Sertaconazole: an antifungal agent for the topical treatment of superficial candidiasis
(Expert Reviews, 2013-02)
Sertaconazole is a useful antifungal agent against mycoses of the skin and mucosa, such as cutaneous, genital and oral candidiasis and tinea pedis. Its antifungal activity is due to inhibition of the ergosterol biosynthesis ...
Fungal diseases: could nanostructured drug delivery systems be a novel paradigm for therapy?
(Dove Medical Press Ltd, 2016-01-01)
Invasive mycoses are a major problem for immunocompromised individuals and patients in intensive care units. Morbidity and mortality rates of these infections are high because of late diagnosis and delayed treatment. ...
Requirement for Ergosterol in V-ATPase Function Underlies Antifungal Activity of Azole Drugs
(Public Library of Science, 2010-06)
Ergosterol is an important constituent of fungal membranes. Azoles inhibit ergosterol biosynthesis, although the cellular basis for their antifungal activity is not understood. We used multiple approaches to demonstrate a ...
Colorimetric MTT assessment of antifungal activity of D0870 against fluconazole-resistant Candida albicans
(Blackwell Wissenschafts-verlag GmbhBerlinAlemanha, 1998)
An azole tolerant endosomal trafficking mutant of Candida albicans is susceptible to azole treatment in a mouse model of vaginal candidiasis.
(Estados Unidos Antimicrobial Agents and Chemotherapy, 2017., 2019-09-24)
We recently reported that a Candida albicans endosomal trafficking mutant continues to grow after treatment with the azole antifungals. Herein, we report that the vps21Δ/Δ mutant does not have a survival advantage over ...
Trafficking through the late endosome significantly impacts candida albicans tolerance of the azole antifungals.
(Estados Unidos: Antimicrobial Agents and Chemotherapy , 2015., 2019-10-02)
The purpose of this study was to characterize the effects of azole treatment upon the integrity of the Candida albicans vacuole and to determine whether, in turn, vacuolar trafficking influences azole susceptibility. ...
Aspergillus spp.: suscetibilidade aos antifúngicos isolados e em associação por diferentes metodologias e detecção de mecanismos de resistência a azólicos
(Universidade Federal de Santa MariaBrasilFarmacologiaUFSMPrograma de Pós-Graduação em Ciências FarmacêuticasCentro de Ciências da Saúde, 2018-01-19)
Aspergillosis is a group of diseases among the main causes of morbidity and mortality in immunosuppressed patients. Aspergillus fumigatus is the most common species that causes invasive and non-invasive aspergillosis in ...
Azole resistance among clinical isolates of Aspergillus fumigatus in Lima-Peru
(Oxford University Press, 2019)
Azole resistance among Aspergillus fumigatus isolates, which is mainly related to mutations in the cyp51A gene, is a concern because it is rising, worldwide disseminated, and associated with treatment failure and death. ...