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Axon micro-dissection and transcriptome profiling reveals the in vivo RNA content of fully differentiated myelinated motor axons
(RNA Society, 2020)
Axonal protein synthesis has been shown to play a role in developmental and regenerative growth, as well as in the maintenance of the axoplasm in steady state. Recent studies have begun to identify the mRNAs localized in ...
New insights on epigenetic mechanisms supporting axonal development: Histone marks and miRNAs
(Wiley Blackwell Publishing, Inc, 2020-12)
Mechanisms supporting axon growth and the establishment of neuronal polarity have remained largely disconnected from their genetic and epigenetic fundamentals. Recently, post-transcriptional modifications of histones ...
Origin of axonal proteins: Is the axon-schwann cell unit a functional syncytium?
(2016)
The structural homeostasis is challenging for neurons, whose axons extend up to meters in large animals, and the axoplasmic mass reaches over a thousand times that of the cell body. Thus, the protein demand may overcome ...
Distinct small non-coding RNA landscape in the axons and released extracellular vesicles of developing primary cortical neurons and the axoplasm of adult nerves
(Taylor and Francis Group, 2021)
Neurons have highlighted the needs for decentralized gene expression and specific RNA function in somato-dendritic and axonal compartments, as well as in intercellular communication via extracellular vesicles (EVs). Despite ...
Origin of axonal proteins: Is the axon-schwann cell unit a functional syncytium?
(CIENCIAS, 2016)
The structural homeostasis is challenging for neurons, whose axons extend up to meters in large animals, and the axoplasmic mass reaches over a thousand times that of the cell body. Thus, the protein demand may overcome ...
Demonstration of ion channel synthesis by isolated squid giant axon provides functional evidence for localized axonal membrane protein translation
(2018)
Local translation of membrane proteins in neuronal subcellular domains like soma, dendrites and axon termini is well-documented. In this study, we isolated the electrical signaling unit of an axon by dissecting giant axons ...
Local regulation of the axonal phenotype, a case of merotrophism
(Sociedad de Biología de Chile, 2005)
Estudio del tráfico local de la proteína L1CAM en axones de neuronas del sistema nervioso central
(Universidad de Chile, 2020)
Las neuronas son células altamente compartimentalizadas y polarizadas en 2
dominios funcional y estructuralmente distintos: el somato-dendrítico y el axonal. La
mantención y diferenciación de ambos dominios es fundamental ...
Demonstration of ion channel synthesis by isolated squid giant axon provides functional evidence for localized axonal membrane protein translation
(Nature Publishing Group, 2018)
© 2018 The Author(s). Local translation of membrane proteins in neuronal subcellular domains like soma, dendrites and axon termini is well-documented. In this study, we isolated the electrical signaling unit of an axon by ...