The axonal region most proximal to soma is the axon initial segment. This region is enriched in voltage-gated sodium channels as well as scaffolding proteins such as ankyrin-G, which allow to this structure to initiate ...

In most dopaminergic neurons of the substantia nigra compacta (SNc), it has been described that the axon emerges from a primary or secondary dendrite. The axonal region most proximal to the soma is the axon initial segment ...

Axon initial segment disassembly has recently begun to be appreciated as an important event in Alzheimer’s disease pathology as it directly impacts neuronal compartmentalization, leading to pathological processes like tau ...

Actions potentials (AP) are generated at the most proximal region of the axon, the axon initial segment (AIS). This unmyelinated region is enriched in sodium and other ionic channels, as well as scaffolding proteins such ...

from a primary or higher order dendrite. Actions potentials are generated at the most proximal region of the axon, the axon initial segment (AIS). This unmyelinated region is enriched in sodium and other ionic channels, ...

The axon initial segment (AIS) is the site of initiation of action potentials and influences action potential waveform, firing pattern, and rate. In view of the fundamental aspects of motor function and behavior that depend ...

For over three decades, action potentials (APs) in nigral dopamine neurons have been thought to have two separate components, re��ecting initiation in the axon initial segment (AIS) and subsequent somatic dendritic (SD) ...

Acquisition of neuronal polarity is a complex process involving cellular and molecular events. The second messenger cAMP is involved in axonal specification through activation of protein kinase A. However, an alternative ...

Las neuronas son células que permiten la conducción nerviosa mediante potenciales de acción. Para lograr esto, evolucionaron y desarrollaron una proyección altamente especializada llamada axón, en la cual se concentran ...