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AXL receptor tyrosine kinase is required for T cell priming and antiviral immunity
(eLife Sciences Publications, 2016-06)
The receptor tyrosine kinase (RTK) AXL is induced in response to type I interferons (IFNs) and limits their production through a negative feedback loop. Enhanced production of type I IFNs in Axl(-/-) dendritic cells (DCs) ...
The Tam Receptor Mertk Protects Against Neuroinvasive Viral Infection By Maintaining Blood-brain Barrier Integrity
(NATURE PUBLISHING GROUPNEW YORK, 2015)
TAM receptor signaling in immune homeostasis
(Annual Reviews, 2015-03)
The TAM receptor tyrosine kinases (RTKs)--TYRO3, AXL, and MERTK--together with their cognate agonists GAS6 and PROS1 play an essential role in the resolution of inflammation. Deficiencies in TAM signaling have been associated ...
FARP1, ARHGEF39, and TIAM2 are essential receptor tyrosine kinase effectors for Rac1-dependent cell motility in human lung adenocarcinoma
(Elsevier, 2021-11)
Despite the undisputable role of the small GTPase Rac1 in the regulation of actin cytoskeleton reorganization, the Rac guanine-nucleotide exchange factors (Rac-GEFs) involved in Rac1-mediated motility and invasion in human ...
Antiphospholipid Antibodies Inhibit Trophoblast Toll-Like Receptor and Inflammasome Negative Regulators
(Wiley-Blackwell, 2018-06-01)
Objective. Women with antiphospholipid antibodies (aPL) are at risk for pregnancy complications associated with poor placentation and placental inflammation. Although these antibodies are heterogeneous, some anti-beta(2) ...
Calix[6]arene bypasses human pancreatic cancer aggressiveness: Downregulation of receptor tyrosine kinases and induction of cell death by reticulum stress and autophagy
(Elsevier Science BvAmsterdamHolanda, 2013)