Buscar
Mostrando ítems 1-10 de 14
Granulocyte-macrophage colony-stimulating factor gene based therapy for acute limb ischemia in a mouse model
(Wiley-Blackwell, 2009-04-01)
Background Granulocyte-colony-stimulating factor (GM-CSF) is a pleiotropic factor for hematopoiesis that stimulates myeloblasts, monoblasts and mobilization of bone marrow stem cells. Therefore, the GM-CSF gene is a potential ...
Avaliação dos efeitos dos peptídeos ricos em prolina do veneno da serpente Bothrops jararaca Bj-PRO-7a e Bj-PRO-10c na revascularização de membros posteriores isquêmicos
(Universidade Federal de Minas GeraisUFMG, 2013-04-03)
Therapeutic angiogenesis has been proposed as an alternative for treating ischemic diseases. Angiotensin converting enzyme inhibitors (ACEi) beyond its antihypertensive effects are also able of enhacing ischemia-induced ...
Plasmid-mediated VEGF gene transfer induces cardiomyogenesis and reduces myocardial infarct size in sheep
(Nature Publishing Group, 2006-08)
We have recently reported that in pigs with chronic myocardial ischemia heart transfection with a plasmid encoding the 165 isoform of human vascular endothelial growth factor (pVEGF165) induces an increase in the mitotic ...
High-dose intramyocardial HMGB1 induces long-term cardioprotection in sheep with myocardial infarction
(Springer Verlag Berlín, 2019-10)
In rodents with acute myocardial infarction (AMI), high mobility group box 1 (HMGB1) injection has produced controversial results. Given the lack of data in large mammals, we searched the dose that would promote angiogenesis ...
Allogeneic mesenchymal stromal cells overexpressing mutant human Hypoxia-inducible factor 1-α (HIF1-α) in an ovine model of acute myocardial infarction
(American Heart Association, 2016-07)
Background-Bone marrow mesenchymal stromal cells (BMMSCs) are cardioprotective in acute myocardial infarction (AMI) because of release of paracrine angiogenic and prosurvival factors. Hypoxia-inducible factor 1-α (HIF1-α), ...