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Hypoxia-reduced nitric oxide synthase activity is partially explained by higher arginase-2 activity and cellular redistribution in human umbilical vein endothelium
(W B SAUNDERS CO LTD, 2011)
Hypoxia relates with altered placental vasodilation, and in isolated endothelial cells, it reduces activity of the endothelial nitric oxide synthase (eNOS) and L-arginine transport. It has been reported that arginase-2 ...
Different profiles of circulating arginase 2 in subtypes of preeclampsia pregnant women
(Elsevier B.V., 2021-06-01)
Background and aims: Preeclampsia (PE) is a gestational hypertensive disease responsible for high maternal and fetal morbidity and mortality. The increase in blood pressure is associated with a decrease in the bioavailability ...
Evidence for cooperative effects in human liver arginase
(1982)
The reaction kinetics of human liver arginase (l-arginine amidinohydrolase, EC 3.5.3.1) in terms of arginine concentration is strikingly altered by varying the pH. Lowering the pH from the optimum (9.5) toward a more ...
The leishmanicidal flavonols quercetin and quercitrin target Leishmania (Leishmania) amazonensis arginase
(ACADEMIC PRESS INC ELSEVIER SCIENCESAN DIEGO, 2012)
Polyamine biosynthesis enzymes are promising drug targets for the treatment of leishmaniasis, Chagas' disease and African sleeping sickness. Arginase, which is a metallohydrolase, is the first enzyme involved in polyamine ...
Arginine Supplementation Induces Arginase Activity and Inhibits TNF-α Synthesis in Mice Spleen Macrophages After Intestinal Obstruction
(American Society for Parenteral and Enteral Nutrition, 2016)
Cascading reaction of arginase and urease on a graphene-based FET for ultrasensitive, real-time detection of arginine
(Elsevier Advanced Technology, 2018-09)
Herein, a biosensor based on a reduced graphene oxide field effect transistor (rGO-FET) functionalized with the cascading enzymes arginase and urease was developed for the detection of L-arginine. Arginase and urease were ...
Downregulation of L-arginine metabolism in dendritic cells induces tolerance to exogenous antigen
(2017-03-01)
Dendritic cells (DC) are potential tools for therapeutic applications and several strategies to generate tolerogenic DCs are under investigation. When activated by cytokines and microbial products, DCs express mediators ...
Arginase levels and their association with Th17-related cytokines, soluble adhesion molecules (sICAM-1 and sVCAM-1) and hemolysis markers among steady-state sickle cell anemia patients
(2010)
Sickle cell anemia (SCA) is characterized by a marked endothelial dysfunction, owing to many factors.Arginine metabolism can be related to the inflammatory chronic state presented by patients, playing a key role in
their ...