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Expression, functionality, and localization of apurinic/apyrimidinic endonucleases in replicative and non-replicative forms of Trypanosoma cruzi
(2014)
Trypanosoma cruzi is the etiological agent of Chagas disease. The parasite has to overcome oxidative damage by ROS/RNS all along its life cycle to survive and to establish a chronic infection. We propose that T. cruzi is ...
Expression, Functionality, and Localization of Apurinic/Apyrimidinic Endonucleases in Replicative and Non‐Replicative Forms of Trypanosoma cruzi
(John Wiley & Sons, 2014)
Trypanosoma cruzi is the etiological agent of Chagas disease. The parasite has to overcome oxidative damage by ROS/RNS all along its life cycle
to survive and to establish a chronic infection. We propose that T. cruzi is ...
XPA deficiency affects the ubiquitin-proteasome system function
(Elsevier, 2020)
Imunoexpressão da proteína endonuclease apurínica/apurimidínica (APE-1) em adenomas pleomórficos e carcinomas ex-adenomas pleomórficos
(Universidade Federal do Rio Grande do NorteBrasilUFRNPROGRAMA DE PÓS-GRADUAÇÃO EM PATOLOGIA ORAL, 2016-02-19)
Introduction: Apurinic/Apyrimidinic Endonuclease 1 (APE-1) is an essential protein for DNA base excision repair (BER) pathway and regulation of redox activities. The ability of malignant cells to recognize and repair DNA ...
Efecto de la expresión de la endonucleasa apurínica/apirimidínica APE1 humana y su dominante negativo en epimastigotes de Trypanosoma cruzi sometidos a estrés oxidativo
(Universidad de Chile, 2016)
La enfermedad de Chagas o Tripanosomiasis Americana es uno de los principales problemas de salud pública en América Latina. Dicha patología determina además severas consecuencias a nivel socioeconómico, tanto en la región ...
The overexpression of TcAP1 endonuclease confers resistance to infective Trypanosoma cruzi trypomastigotes against oxidative DNA damage
(Wiley, 2018)
Trypanosoma cruzi, the causative agent of Chagas' disease survives to DNA damage generated by ROS/RNS inside to their different hosts. In recent eukaryotes, oxidative DNA damage is repaired mainly by the Base Excision ...
Inibição da função redox de APE1/REF-1 e sua influência na regulação transcricional em um modelo de estimulação inflamatória
(BrasilUFRNPROGRAMA DE PÓS-GRADUAÇÃO EM CIÊNCIAS DA SAÚDE, 2016-12-09)
The human apurinic/apyrimidinic endonuclease 1 (APE1/REF-1) is a
multifunctional enzyme that plays a role in both DNA repair and transcription
pathways, being considered a hub protein, controlling key pathways in ...
Transcriptional Up-Regulation of APE1/Ref-1 in hepatic tumor: Role in hepatocytes resistance to oxidative stress and apoptosis
(Public Library of Science, 2015-12)
Objective Human Hepatocellular Carcinoma (HCC) is the fifth most frequent neoplasm worldwide and the most serious complication of long-standing chronic liver diseases (CLD). Its development is associated with chronic ...