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Apotransferrin-induced recovery after hypoxic/ischaemic injury on myelination
(Sage Publications, 2010-11)
We have previously demonstrated that aTf (apotransferrin) accelerates maturation of OLs (oligodendrocytes) in vitro as well as in vivo. The purpose of this study is to determine whether aTf plays a functional role in a ...
Combination therapy of apo-transferrin and thyroid hormones enhances remyelination
(Wiley-liss, div John Wiley & Sons Inc., 2020-08)
The current study presents two different approaches with a view to elucidating the interaction between thyroid hormones (TH) and apo-transferrin (aTf) and their role in myelination and remyelination. First, in vitro assays ...
Inhalation of growth factors and apo-transferrin to protect and repair the hypoxic-ischemic brain
(Elsevier, 2016-07)
Hypoxic-ischemic brain damage is a major contributor to chronic neurological dysfunction and acute mortality in infants as well as in adults. In this review, we summarize recent publications demonstrating that the intranasal ...
Intranasal administration of atf protects and repairs the neonatal white matter after a cerebral hypoxic-ischemic event
(Wiley-liss, Div John Wiley & Sons Inc, 2012-10)
Our previous studies showed that the intracerebral injection of apotransferrin (aTf) attenuates white matter damage and accelerates the remyelination process in a neonatal rat model of cerebral hypoxia-ischemia (HI) injury. ...
Vesicular transport of Fe and interaction with other metal ions in polarized Caco2 Cell monolayers
(Sociedad de Biología de Chile, 2006)
Oligodendroglial cell differentiation in rat brain is accelerated by the intracranial injection of apotransferrin
(C M B Association, 2000-01)
Abstract
In the present paper we first studied the brain distribution and the time and dose dependent effects of apotransferrin, after its intracranial injection into young rats and at different post-natal ages. Its action ...
Extracellular vesicles containing the transferrin receptor as nanocarriers of apotransferrin
(Wiley Blackwell Publishing, Inc, 2020-04)
Previous work by our group has shown the pro-differentiating effects of apotransferrin (aTf) on oligodendroglial cells in vivo and in vitro. Further studies showed the remyelinating effect of aTf in animal demyelination ...
Extracellular vesicles containing the transferrin receptor as nanocarriers of apotransferrin
(Wiley Blackwell Publishing, Inc, 2020-04)
Previous work by our group has shown the pro-differentiating effects of apotransferrin (aTf) on oligodendroglial cells in vivo and in vitro. Further studies showed the remyelinating effect of aTf in animal demyelination ...
Nerve degeneration is prevented by a single intraneural apotransferrin injection into colchicines injured sciatic nerves in the rat
(Elsevier Science, 2006-01)
In this work, we have immunohistochemically analyzed the effects of single injections of apotransferrin (aTf) on the expression of myelin (myelin basic proteins [MBPs]) and axonal (protein gene product 9.5 [PGP 9.5] and ...
Binding of [Cr(phen)3]3+to transferrin at extracellular and endosomalpHs: Potential application in photodynamic therapy
(Elsevier Science, 2014-06)
Background Transferrin is an iron-binding blood plasma glycoprotein that controls the level of free iron in biological fluids. This protein has been deeply studied in the past few years because of its potential use as a ...