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Antitumor properties of an anti-idiotypic monoclonal antibody in relation to N-glycolyl-containing gangliosides
(Spandidos Publications, 2000-07)
We examined the antitumor effects of 1E10 monoclonal antibody, an anti-idiotypic IgG to an IgM monoclonal antibody, named P3, that reacts specifically with N-glycolyl-containing gangliosides and also recognizes antigens ...
In silico directed evolution in antibody engineering: a promising approach to improvement antitumor biopharmaceuticals
(Fiocruz/Instituto de Tecnologia em Imunobiológicos, 2019)
Protective, anti-tumor monoclonal antibody recognizes a conformational epitope similar to melibiose at the surface of invasive murine melanoma cells
(Mary Ann Liebert Inc Publ, 2002-10-01)
Polyclonal and monoclonal antibodies (MAbs) have been raised against B16F10 cells collected from growing tumors in vivo or grown in culture media supplemented with normal mouse serum to avoid xenogeneic reactivity. Antibody ...
In silico directed evolution in antibody engineering: a promising approach to improvement antitumor biopharmaceuticals
(Fiocruz/Instituto de Tecnologia em Imunobiológicos, 2019)
Anti-ganglioside antibodies induced in chickens by an alum-adsorbed anti-idiotype antibody targeting NeuGcGM3
(Frontiers, 2013-01)
Racotumomab is a murine anti-idiotype cancer vaccine targeting NeuGcGM3 on melanoma, breast, and lung cancer. In order to characterize the immunogenicity of alum-adsorbed racotumomab in a non-clinical setting, Leghorn ...
Anti-tumor activities of peptides corresponding to conserved complementary determining regions from different immunoglobulins
(Elsevier B.V., 2014-09-01)
Short synthetic peptides corresponding to sequences of complementarity-determining regions (CDRs) from different immunoglobulin families have been shown to induce antimicrobial, antiviral and antitumor activities regardless ...
Restoration of antitumor immunity through anti-MICA antibodies elicited with a chimeric protein
(BMJ Publishing Group, 2020-06)
Background Natural killer and cytotoxic CD8+ T cells are major players during antitumor immunity. They express NKG2D, an activating receptor that promotes tumor elimination through recognition of the MHC class I chain-related ...
Antitumor effects in vitro and in vivo and mechanisms of protection against melanoma B16F10-Nex2 cells by fastuosain, a cysteine proteinase from Bromelia fastuosa
(Neoplasia Press, 2007-09-01)
In the present work, the antitumor effect of fastuosain, a cysteine proteinase from Bromelia fastuosa, was investigated. in the intravenous model of lung colonization in C57Bl/6 mice, fastuosain and bromelain injected ...
Antitumor effects in vitro and in vivo and mechanisms of protection against melanoma B16F10-Nex2 cells by fastuosain, a cysteine proteinase from Bromelia fastuosa
(Neoplasia Press, 2007-09-01)
In the present work, the antitumor effect of fastuosain, a cysteine proteinase from Bromelia fastuosa, was investigated. In the intravenous model of lung colonization in C57Bl/6 mice, fastuosain and bromelain injected ...