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Encapsulating Anti-Parasite Benzimidazole Drugs into Lipid-Coated Calcium Phosphate Nanoparticles to Efficiently Induce Skin Cancer Cell Apoptosis
(2021-06-15)
Benzimidazole (BMZ) family of anti-worm drugs has been now repurposed as anti-cancer drugs. However, offering a general reformulation method for these drugs is essential due to their hydrophobicity and low aqueous solubility. ...
Estudo fitoquímico da espécie vegetal Calophyllum brasiliense (Clusiaceae) visando a seleção de compostos com ação antiparasitária e anttumoral
(Universidade Federal de São Paulo, 2015-01-10)
This work consists of phytochemical study and evaluation of the biological activity of the methanol extract of the bark of the trunk and essential oils from leaves, twigs and bark of Calophyllum brasiliense (Clusiaceae). ...
Avaliação do potencial antimicrobiano e antiparasitário de oligossacarídeos de quitosana
(Universidade Federal do Rio Grande do NorteBrasilUFRNPROGRAMA DE PÓS-GRADUAÇÃO EM CIÊNCIAS FARMACÊUTICAS, 2020-07-31)
The increase in outbreaks of infectious diseases, the worldwide progression of
microbial resistance and the high impact of neglected tropical diseases reinforces the
search for new molecules with antimicrobial potential. ...
TNF-α blockade suppresses pericystic inflammation following anthelmintic treatment in porcine neurocysticercosis
(Public Library of Science, 2017)
BACKGROUND: Neurocysticercosis (NCC) is an infection of the brain with the larval cyst of the tapeworm, Taenia solium. Cysticidal treatment induces parasite killing resulting in a post inflammatory response and seizures, ...
Synthesis, structural diversification, biological activities and biotransformation of dibenzylacetones : simple chemistry furnishing potent compounds
(Universidade Federal de São CarlosUFSCarPrograma de Pós-Graduação em Química - PPGQCâmpus São Carlos, 2016-02-23)
The structural diversity of known compounds holding two benzene rings
directly connected to each other (Bis-phenyl), or separated by a carbon-chain (Bisarylalkane),
is nowadays generated intensive scientific studies ...
Isolamento, caracterização estrutural e avaliação do potencial farmacológico de metabólitos especiais das folhas de Schinus terebinthifolius (Anacardiaceae)
(Universidade Federal de São Paulo, 2014-09-09)
The present work was performed a bioguided phytochemical study by antiparasitic and cytotoxic activities of extracts from leaves of Schinus terebinthifolius Raddi (Anarcadiaceae). Initially, this extract showed in vitro ...
Síntese de complexos de platina(II) com ligantes lipofílicos derivados de 1,3,4-oxadiazol e piperazina e seus estudos biológicos
(Universidade Federal de Minas GeraisBrasilICX - DEPARTAMENTO DE QUÍMICAPrograma de Pós-Graduação em QuímicaUFMG, 2022-02-23)
The cisplatin was the first inorganic compound used as an antitumoral drug, but its side effects and resistance mechanism drove the search for more active and less toxic analog complexes. The ligands have important role ...