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Antifungal therapy: New advances in the understanding and treatment of mycosis
(2017-01-23)
The high rates of morbidity and mortality caused by fungal infections are associated with the current limited antifungal arsenal and the high toxicity of the compounds. Additionally, identifying novel drug targets is ...
Molecular markers of antifungal resistance: Potential uses in routine practice and future perspectives
(Multidisciplinary Digital Publishing Institute, 2021-03)
Antifungal susceptibility testing (AST) has come to establish itself as a mandatory routine in clinical practice. At the same time, the mycological diagnosis seems to have headed in the direction of non-culture-based ...
Searching new antifungals: The use of in vitro and in vivo methods for evaluation of natural compounds
(2016-04-01)
In the last decades, the increased number of immunocompromised patients has led to the emergence of many forms of fungal infections. Furthermore, there are a restricted arsenal of antifungals available and an increase in ...
Antifungal stewardship in low- and middle-income countries
(Springer Nature, 2019-07)
Anfifugal stewardship refers to coordinated interventions designed to improve and measere the appropiate use of antifungals by promouting the selection of the optimal antifungal drug regimen,dose,duration of therapy,and ...
Disseminated Amphotericin-Resistant Fusariosis in Acute Leukemia Patients: Report of Two Cases
(2013-01-01)
Disseminated fusariosis has emerged as a significant, usually fatal infection in immunocompromised hosts despite antifungal treatment. We describe here two patients with acute leukemia who developed disseminated ...
Disseminated Amphotericin-Resistant Fusariosis in Acute Leukemia Patients: Report of Two Cases
(2013-01-01)
Disseminated fusariosis has emerged as a significant, usually fatal infection in immunocompromised hosts despite antifungal treatment. We describe here two patients with acute leukemia who developed disseminated ...
Candida infections, causes, targets and resistance mechanisms. Traditional and alternative antifungal agents
(Hindawi Publishing Corporation, 2013-06)
The genus Candida includes about 200 different species, but only a few species are human opportunistic pathogens and cause infections when the host becomes debilitated or immunocompromised. Candida infections can be ...
Alternative treatment of fungal infections: Synergy with non-antifungal agents
(Wiley Blackwell Publishing, Inc, 2021-03)
Fungal infections are responsible for high mortality rates in immunocompromised and high-risk surgical patients. Therapy failures during the last decades due to increasing multidrug resistance demand innovative strategies ...
Species distribution and antifungal susceptibility profile of Candida isolates from bloodstream infections in Lima, Peru
(Microbiology Society, 2014)
Yeast identification and in vitro susceptibility testing provide helpful information for appropriate administration of antifungal treatments; however, few reports from the Latin American region have been published. The aim ...