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Antidepressant responses in direct comparisons of melancholic and non-melancholic depression
(2020)
Background: Efforts to develop less heterogeneous, more clinically useful diagnostic categories for depressive disorders include renewed interest in the
concept of melancholia (Mel). However, clinical or biological ...
Safety limits of antidepressant use plus combinations: Focus on cardiovascular function
(2018-01-01)
Background: Antidepressants have been widely prescribed for depression, anxiety, sleep disorders, and in the management of behavioural symptoms of adult-old patients. Although generally safe, newer generation antidepressants ...
Antidepressant combination for major depression in incomplete responders-a systematic review
(Elsevier B.V., 2013-01-10)
Background: Antidepressant combination has been suggested as a strategy to increase treatment efficacy. the objective of this study was to perform a systematic review and meta-analysis of studies that assessed the effect ...
Antidepressants versus placebo for the treatment of bulimia nervosa: a systematic review
(Blackwell Science Asia, 2000-04-01)
Objective: the objective of this study was to valuate the effectiveness, tolerability and acceptability of various classes of antidepressants compared with placebo in the treatment of bulimia nervosa.Method: A meta-analysis ...
A quantitative review on outcome-to-antidepressants in melancholic unipolar depression
(Elsevier Ireland, 2018-07)
The aim of this study was to explore outcome to antidepressants profile in melancholic unipolar depression. We conducted a systematic review of electronic databases and meta-analysis of randomized and nonrandomized trials ...
Effect of antidepressants on melatonin metabolite in depressed patients
(SAGE PUBLICATIONS LTD, 2009)
Antidepressants increase melatonin levels, but it is still unclear whether this effect is related to the improvement of depressive symptoms or to unrelated pharmacological action of antidepressants. To answer this question, ...
Combination of Antidepressants in the Treatment of Major Depressive Disorder A Systematic Review and Meta-Analysis
(Lippincott Williams & Wilkins, 2012-04-01)
The objective was to perform a systematic review and meta-analysis of studies that assessed the effect of the combination of antidepressants from the beginning of the treatment of major depressive disorder. Studies were ...
Mixed Depression: Clinical Features and Predictors of Its Onset Associated with Antidepressant Use
(S. Karger AG, Basel, 2014)
Background: Mixed depression (MxD) is narrowly defined in
the DSM-IV and somewhat broader in the DSM-5, although
both exclude psychomotor agitation as a diagnostic criterion.
This article proposes a clinical description ...
Efficacy and Tolerability of Combination Treatments for Major Depression: Antidepressants plus Second-Generation Antipsychotics vs. Esketamine vs. Lithium
(2021)
Abstract
Background: Successful treatment of major depressive disorder (MDD) can be challenging, and failures ("treatment-resistant depression" [TRD])
are frequent. Steps to address TRD include increasing antidepressant ...
Declining efficacy in controlled trials of antidepressants: effects of placebo dropout.
(Oxford University Press, 2014)
Drug-placebo differences (effect-sizes) in controlled trials of antidepressants for major depressive episodes have declined for several decades, in association with selectively increasing clinical improvement associated ...