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Cetuximab-mediated cellular cytotoxicity is inhibited by HLA-E membrane expression in colon cancer cells
(Sage Publications Ltd, 2009-04)
Cetuximab, an anti-epidermal growth factor receptor monoclonal antibody, has been shown to increase the median survival of colorectal cancer patients. We previously reported that the expression of HLA-E is significantly ...
Analysis of complement-mediated lysis of simian immunodeficiency virus (SIV) and SIV-infected cells reveals sex differences in vaccine-induced immune responses in rhesus macaques
(American Society for Microbiology, 2018)
An effective human immunodeficiency virus (HIV) vaccine has yet to be developed, and defining immune correlates of protection against HIV infection is of paramount importance to inform future vaccine design. The complement ...
Compartment-specific expression of natural killer cell markers in renal transplantation: Immune profile in acute rejection
(2016-04-01)
Natural killer (NK) cells have been implicated in graft dysfunction. Here, we formulated hypothesis that distinct patterns of expression NK cells markers correlated with acute rejection in kidney transplantation. Therefore, ...
A combination of the cytokinesis-block micronucleus cytome assay and centromeric identification for evaluation of the genotoxicity of dicamba
(Elsevier Ireland, 2011-12)
The purpose of this study was to further investigate the cytotoxic and genotoxic effects of dicamba and Banvel® employing the cytokinesis-block micronucleus cytome (CBMN-cyt) assay estimated by the analysis of the nuclear ...
IL-15 and IL-2 increase Cetuximab-mediated cellular cytotoxicity against triple negative breast cancer cell lines expressing EGFR
(Springer, 2011-11)
Triple negative breast cancer (TNBC) patients are not likely to benefit from anti-estrogen or anti-HER2 therapy and this phenotype is associated with a more aggressive clinical course and worse clinical outcome. Taking ...
Cytotoxicity-related lipidomic changes induced in double-hit Diffuse Large B-Cell Lymphoma after treatment with statins in vitro
(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2022-05-31)
Diffuse Large B-Cell Lymphoma (DLBCL) is the most common hematologic malignancy in the world and one of the deadliest. Since the introduction of anti-CD20 blocking antibodies prognosis has dramatically improved; however, ...
Waning and boosting of antibody Fc-effector functions upon SARS-CoV-2 vaccination
(SPRINGER INTERNATIONAL PUBLISHING AG, 2023)
Efficiency of SARS-CoV-2 vaccines has long been attributed to the neutralising capacity of the antibodies that are produced upon prime-boost vaccinations. Here authors show that upon vaccination with CoronaVac and BNT162b2 ...
Evaluation of Different Parameters of Humoral and Cellular Immune Responses in HIV Serodiscordant Heterosexual Couples: Humoral Response Potentially Implicated in Modulating Transmission Rates
(Elsevier, 2017-12)
As the HIV/AIDS pandemic still progresses, understanding the mechanisms governing viral transmission as well as protection from HIV acquisition is fundamental. In this context, cohorts of HIV serodiscordant heterosexual ...
Nephrotoxicity caused by brown spider venom phospholipase-D (dermonecrotic toxin) depends on catalytic activity
(Elsevier B.V., 2008-11-01)
Bites from brown spiders (Loxosceles genus) have clinical manifestations including skin necrosis with gravitational spreading, and systemic involvement that may include renal failure, hemolysis, and thrombocytopenia. Mice ...