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Atorvastatin and diacerein reduce insulin resistance and increase disease tolerance in rats with sepsis
(2018-05-09)
Background: Sepsis is one of the leading causes of death among hospitalized patients. At the onset of this condition, there is an over-production of pro-inflammatory mediators that contribute to organ failure and death. ...
Challenges in the diagnosis and management of neonatal sepsis
(Oxford University Press, 2015)
Neonatal sepsis is the third leading cause of neonatal mortality and a major public health problem, especially in developing countries. Although recent medical advances have improved neonatal care, many challenges remain ...
De-escalation of antimicrobial treatment for adults with sepsis, severe sepsis or septic shock
(Wiley-Blackwell, 2013-01-01)
BackgroundMortality rates among patients with sepsis, severe sepsis or septic shock are highly variable throughout different regions or services and can be upwards of 50%. Empirical broad-spectrum antimicrobial treatment ...
Randomized controlled trial of lactoferrin for prevention of sepsis in peruvian neonates less than 2500 g
(Wolters Kluwer Health, 2015)
BACKGROUND: Lactoferrin (LF) is a broad-spectrum antimicrobial and immunomodulatory milk glycoprotein. OBJECTIVE: To determine the effect of bovine LF on the prevention of the first episode of late-onset sepsis in Peruvian ...
Sepsis: from bench to bedside
(Faculdade de Medicina / USP, 2008)
Sepsis is a syndrome related to severe infections. It is defined as the systemic host response to microorganisms in previously sterile tissues and is characterized by end-organ dysfunction away from the primary site of ...
TNFR1 signaling contributes to T cell anergy during staphylococcus aureus sepsis
(Frontiers Media SA, 2018-08)
Early research on sepsis has focused on the initial hyper-inflammatory, cytokine mediated phase of the disorder whereas the events that govern the concomitant and subsequent anti-inflammatory compensatory response are not ...
Um novo inibidor de tripsina multifuncional de sementes de Erythrina velutina: caracterizacao e propriedades farmacologicas
(Universidade Federal do Rio Grande do NorteBRUFRNPrograma de Pós-Graduação em BioquímicaBioquímica; Biologia Molecular, 2012-10-24)
Lactoferrin for prevention of neonatal sepsis
(Springer Verlag, 2014)
Preterm neonates are at risk to acquire infections. In addition to the high mortality associated with sepsis, these patients are at risk for long-term disabilities, particularly neurodevelopment impairment. Several ...