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Efetividade clínica dos medicamentos biológicos anti-TNF, biológicos não anti-TNF e sintético alvo-específico no tratamento da artrite reumatoide.
(Universidade Federal de Minas GeraisBrasilFARMACIA - FACULDADE DE FARMACIAPrograma de Pós-Graduação em Medicamentos e Assistencia FarmaceuticaUFMG, 2022-02-24)
Introduction: Rheumatoid Arthritis is a systemic, chronical inflammatory disease
associated to peripheral polyarthritis, which leads to deformity and destruction of
joints due to erosion of cartilage and bone. Treatment ...
Immunogenicity to biological drugs in psoriasis and psoriatic arthritis
(Hospital Clinicas, Brasil, 2021)
Monoclonal antibodies or fusion proteins, defined as biological drugs, have modified the natural history of numerous immune-mediated disorders, allowing the development of therapies aimed at blocking the pathophysiological ...
Small Molecules as Anti-TNF Drugs
(Bentham Science Publishers, 2015)
Tumor necrosis factor (TNF, TNF-α, cachectin) is a pleiotropic, proinflammatory cytokine with multiple biological effects, many of which are not yet fully understood. Although TNF was initially described as an anti-tumor ...
Anti-TNF and postoperative complications in abdominal crohn's disease surgery
(2019-01-01)
Background: Biological therapy with anti-Tumour Necrosis Factor (TNF)-α agents revolutionised the treatment of inflammatory bowel disease over the last decades. However, there may be an increased risk of postoperative ...
Hypusine modification of the ribosome-binding protein eIF5A, a target for new anti-inflammatory drugs: Understanding the action of the inhibitor GC7 on a murine macrophage cell line
(2014-01-30)
Inflammation is part of an important mechanism triggered by the innate immune response that rapidly responds to invading microorganisms and tissue injury. One important elicitor of the inflammatory response is the Gram-negative ...
Hypusine Modification of the Ribosome-binding Protein eIF5A, a Target for New Anti-Inflammatory Drugs: Understanding the Action of the Inhibitor GC7 on a Murine Macrophage Cell Line
(Bentham Science Publ Ltd, 2014-01-01)
Inflammation is part of an important mechanism triggered by the innate immune response that rapidly responds to invading microorganisms and tissue injury. One important elicitor of the inflammatory response is the Gram-negative ...
Cost analysis of drug therapy in rheumatoid arthritis
(UNIV SAO PAULO, CONJUNTO QUIMICAS, 2008)
With the aim to compare the cost of treatment for rheumatoid arthritis therapy with desease-modifying antirheumatic drugs (DMARDS) for a 48-month period, were studied five different treatment stage based on clinical protocols ...