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Autolytic Mycobacterium leprae Hsp65 fragments may act as biological markers for autoimmune diseases
(ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2011)
Investigating the proteolytic activity of the recombinant Mycobacterium leprae Heat Shock Protein of 65 kDa (rHsp65), chaperonin 2 (cpn2), we observed that it displays high instability. The fragmentation process starts at ...
Heat Shock Protein 60 Antibodies Are Associated With a Risk Factor for Cardiovascular Disease in Bedridden Elderly Patients
(2020-06-12)
Frailty, in elderly people, represents multiple deficiencies in different organs and is characterized by decreased physiological reserves and greater vulnerability to stressors. Bedridden elderly, with cardiovascular disease ...
Mycobacterium leprae Hsp65 administration reduces the lifespan of aged high antibody producer mice
(2014-03-26)
Abstract
Background
Aging process may result in immune modifications that lead to disruption of innate and acquired immunity mechanisms that may induce chronic-degenerative ...
Mycobacterium leprae Hsp65 administration reduces the lifespan of aged high antibody producer mice
(2014-03-26)
Abstract
Background
Aging process may result in immune modifications that lead to disruption of innate and acquired immunity mechanisms that may induce chronic-degenerative ...
Th1 polarized response induced by intramuscular DNA-HSP65 immunization is preserved in experimental atherosclerosis
(Associação Brasileira de Divulgação Científica (ABRADIC), 2007-11-01)
We previously reported that a DNA vaccine constructed with the heat shock protein (HSP65) gene from Mycobacterium leprae (DNA-HSP65) was protective and also therapeutic in experimental tuberculosis. By the intramuscular ...
Th1 polarized response induced by intramuscular DNA-HSP65 immunization is preserved in experimental atherosclerosis
(Associação Brasileira de Divulgação Científica (ABRADIC), 2007-11-01)
We previously reported that a DNA vaccine constructed with the heat shock protein (HSP65) gene from Mycobacterium leprae (DNA-HSP65) was protective and also therapeutic in experimental tuberculosis. By the intramuscular ...
Th1 polarized response induced by intramuscular DNA-HSP65 immunization is preserved in experimental atherosclerosis
(Associação Brasileira de Divulgação Científica (ABRADIC), 2014)
Auto-antibodies do not influence development of atherosclerotic plaques in rheumatoid arthritis
(ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2008)
Background: Many questions remain unanswered about premature atherosclerosis in rheumatoid arthritis (RA). Besides inflammation, some studies have suggested the role of autoantibodies on its pathogenesis. Objective: The ...
Administration of M. leprae Hsp65 Interferes with the Murine Lupus Progression
(PUBLIC LIBRARY SCIENCE, 2008)
The heat shock protein [Hsp] family guides several steps during protein synthesis, are abundant in prokaryotic and eukaryotic cells, and are highly conserved during evolution. The Hsp60 family is involved in assembly and ...