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The Anrep effect: 100 years later
(American Physiological Society, 2013-01-15)
Cingolani HE, Pérez NG, Cingolani OH, Ennis IL. The Anrep effect: 100 years later. Am J Physiol Heart Circ Physiol 304: H175–H182, 2013. First published November 16, 2012; doi:10.1152/ajpheart.00508.2012.—Myocardial stretch ...
The Anrep effect requires transactivation of the epidermal growth factor receptor
(Wiley Blackwell Publishing, Inc, 2010-05)
Myocardial stretch elicits a biphasic contractile response: the Frank-Starling mechanism followed by the slow force response (SFR) or Anrep effect. In this study we hypothesized that the SFR depends on epidermal growth ...
The autocrine/paracrine loop after myocardial stretch: Mineralocorticoid receptor activation
(Bentham Science Publishers, 2013-01)
The stretch of cardiac muscle increases developed force in two phases. The first phase, which occurs rapidly, constitutes the well-known Frank-Starling mechanism and it is generally attributed to enhanced myofilament ...
Mechanosignaling in the vasculature: emerging concepts in sensing, transduction and physiological responses
(American Physiological Society, 2015-06)
Cells are constantly exposed to mechanical forces that play a role in modulating cellular structure and function. The cardiovascular system experiences physical forces in the form of shear stress and stretch associated ...