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Protocol to refine intestinal motility test in mice
(2004-07-01)
We propose a new protocol intended to conform to the 3Rs (replacement, reduction, and refinement) principle, using animals fasted for 3 h to control intestinal motility, which reduced stress in the animals. In this new ...
Corrositex®, BCOP and HET-CAM as alternative methods to animal experimentation
(2009-10-01)
Tests in animals are used as models in toxicological and investigative studies. However, such tests have been considered inhumane because they can cause pain and suffering to experimental animals, while these methods can ...
Protocol to refine intestinal motility test in mice
(2004-07-01)
We propose a new protocol intended to conform to the 3Rs (replacement, reduction, and refinement) principle, using animals fasted for 3 h to control intestinal motility, which reduced stress in the animals. In this new ...
Corrositex®, BCOP and HET-CAM as alternative methods to animal experimentation
(Universidade de São Paulo (USP), Faculdade de Ciências Farmacêuticas, 2009-12-01)
Testes em animais são utilizados como modelos em estudos toxicológicos e de pesquisa. Entretanto, tais testes têm sido considerados desumanos, porque causam dor e sofrimento aos animais experimentais, porquanto estes métodos ...
Alternative Host Models for Testing Anti-Protozoal or Antifungal Compounds and Fungal Infection
(Bentham Science Publ Ltd, 2018)
The neglected tropical diseases (NTDs) are caused by several parasites, fungi, bacteria and viruses and affect more than one billion people in the world. The control and prevention against NTDs need implementation of ...
Zebrafish as an alternative animal model in human and animal vaccination research
(Springer, 2020-05-07)
Much of medical research relies on animal models to deepen knowledge of the causes of animal and human diseases, as well as to enable the development of innovative therapies. Despite rodents being the most widely used ...
Comparison of five methods for the determination of lethal dose in acute toxicity studies
(Associação Brasileira de Divulgação Científica, 2015)
Determination of eye irritation potential of low-irritant products: comparison of in vitro results with the in vivo draize rabbit test
(Instituto de Tecnologia do Paraná, 2014)