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Androgen receptor signaling in prostate cancer: Genetic and molecular aspects
(2014-01-01)
The prostate is an accessory sex gland of the male reproductive system, which produces alkaline prostatic fluid, capable of ensuring the spermatic viability to fertilize eggs within the female reproductive system. Functionally, ...
Relationship between androgen receptor gene structure and protein function. Structural gene defects that promote androgen insensitivity in man Estructura del gen del receptor de andrógeno y función de la proteína. Defectos estructurales del gen que determ
(1996)
The human androgen receptor is a member of the superfamily of steroid hormone receptors and contains three functional domains: an amino-terminal region involved in the expression of androgen regulated genes, a central ...
Androgens, brain and androgen deprivation therapy in paraphilic disorders: A narrative review
(Wiley, 2022)
Sexual delinquency is a global problem where those with paraphilic disorders, such as paedophiles, are more likely to commit and reoffend. Androgen deprivation therapy (ADT) has been suggested as a solution. The objective ...
Androgen sensitivity gateway to COVID-19 disease severity
(2020-01-01)
In this communication, we present arguments for androgen sensitivity as a likely determinant of COVID-19 disease severity. The androgen sensitivity model explains why males are more likely to develop severe symptoms while ...
The Role of Androgen Signaling in Male Sexual Development at Puberty
(Oxford University Press, 2021-02)
Puberty is characterized by major changes in the anatomy and function of reproductive organs. Androgen activity is low before puberty, but during pubertal development, the testes resume the production of androgens. Major ...
Estrogen-induced inhibition of spermatogenesis in zebrafish is largely reversed by androgen
(Bioscientifica Ltd, 2018-05-01)
The hormonal regulation of spermatogenesis involves both gonadotropins and steroid hormones. Long-term in vivo exposure of adult zebrafish to estrogen impaired spermatogenesis associated with an androgen insufficiency, ...
Androgen receptors and experimental bone loss - an in vivo and in vitro study
(Elsevier B. V., 2015)
Testosterone is a sex hormone that exhibits many functions beyond reproduction; one such function is the regulation of bone metabolism. The role played by androgen receptors during testosterone-mediated biological processes ...
Androgen receptor in the Mongolian gerbil ventral prostate: Evaluation during different phases of postnatal development and following androgen blockage
(Pergamon-Elsevier B.V. Ltd, 2008-12-01)
The normal growth, differentiation and maintenance of the morphofunctional integrity of the prostate gland are dependent on the interaction of constant levels of androgens with their receptors. The need to study the responses ...