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Astroglial mGlu3 receptors promote alpha-secretase-mediated amyloid precursor protein cleavage
(Elsevier, 2013-11)
Amyloid precursor protein (APP) shedding yields the Alzheimer´s disease (AD)-related peptide amyloid B (AB) through beta- and gamma-secretase cleavage. Alternatively, alpha-secretase cleavage generates a soluble and ...
Adaptor protein 2-mediated endocytosis of the beta-secretase bace1 is dispensable for amyloid precursor protein processing
(AMERICAN SOCIETY FOR CELL BIOLOGY, 2012)
UV Accelerates Amyloid Precursor Protein (APP) Processing and Disrupts APP Axonal Transport
(Society for Neuroscience, 2014-03)
Overexpression and/or abnormal cleavage of amyloid precursor protein (APP) are linked to Alzheimer's disease (AD) development and progression. However, the molecular mechanisms regulating cellular levels of APP or its ...
TrkA receptor activation by nerve growth factor induces shedding of the p75 neurotrophin receptor followed by endosomal gamma-secretase-mediated release of the p75 intracellular domain
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2007)
Neurotrophins are trophic factors that regulate important neuronal functions. They bind two unrelated receptors, the Trk family of receptor-tyrosine kinases and the p75 neurotrophin receptor (p75). p75 was recently identified ...
ApoER2 expression increases AB production while decreasing Amyloid Precursor Protein (APP) endocytosis: Possible role in the partitioning of APP into lipid rafts and in the regulation of Y-secretase activity
(2007)
Abstract
Background
The generation of the amyloid-β peptide (Aβ) through the proteolytic processing of the amyloid precursor protein (APP) is a central event in the pathogenesis ...